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The purpose of this study in patients suffering from acute lung injury is to determine whether positive end-expiratory pressure (PEEP) setting guided by electrical impedance tomography (EIT) influences pulmonary gas exchange, lung mechanics, ventilation/perfusion matching and homogeneity of regional ventilation when compared to other PEEP setting strategies such as the open lung concept or the ARDSnet protocol.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute Lung Injury / ARDS | Experimental | Patient under mechanical suffering from ALI or ARDS |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PEEP titration | Procedure | PEEP is set according to the following protocols, respectively, in a randomized order: ARDSnet table, Open Lung strategy, guided by EIT |
|
| Measure | Description | Time Frame |
|---|---|---|
| homogeneity of regional ventilation delay | influence of different PEEP titration strategies on homogeneity of regional ventilation delay measured by electrical impedance tomography | up to eight hours |
| Measure | Description | Time Frame |
|---|---|---|
| pulmonary gas exchange, lung mechanics and ventilation/perfusion matching | influence of different PEEP titration strategies on pulmonary gas exchange, lung mechanics and ventilation/perfusion matching | up to eight hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Christian Putensen, Prof., MD | Contact | +49-228-28714119 | christian.putensen@ukb.uni-bonn.de | |
| Thomas Muders, MD | Contact | t.muders@uni-bonn.de |
| Name | Affiliation | Role |
|---|---|---|
| Christian Putensen, MD, Prof | University of Bonn | Study Chair |
| Thomas Muders, MD | University of Bonn | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | Recruiting | Bonn | 53105 | Germany |
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| ID | Term |
|---|---|
| D055371 | Acute Lung Injury |
| D012128 | Respiratory Distress Syndrome |
| D012131 | Respiratory Insufficiency |
| ID | Term |
|---|---|
| D055370 | Lung Injury |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
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