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Null hypothesis:
No significant effect of vitamin C 500 mg Supplementation on the severity of micro-vascular complications of type 2 Diabetes Mellitus (DM).
Alternative hypothesis:
There is a significant effect of vitamin C 500mg supplementation on the severity of the micro-vascular complications of type 2DM.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vitamin C supplementation plus oral hypoglycemic agents arm | Experimental | This group will receive vitamin C supplementation 500mg daily for one month and then assessment will done for the patients. |
|
| Type 2DM patients receiving oral hypoglycemic agents alone | Active Comparator | this group is the control group who receive oral hypoglycemic agents alone |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vitamin C | Dietary Supplement | Vitamin C supplementation 500mg |
|
| Measure | Description | Time Frame |
|---|---|---|
| improving the renal function | vitamin c supplementation act as an antioxidants which reduce the oxidative stress and then can improve the renal function. | the renal function will be measure at day 1 and after one month |
| Measure | Description | Time Frame |
|---|---|---|
| Vitamin C can improve the visual fields | the damage of the eye can be prevented by decreasing the oxidative stress in the eye, this can be accomplished by vitamin C. | the visual field will be assesed at day 1 and after one month |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hamdan Z Hamdan, MBBS, Msc | Contact | +249912468264 | hamdanology@hotmail.com | |
| Maha I Mohammed, MBBS, PhD | Contact | +249912230895 |
| Name | Affiliation | Role |
|---|---|---|
| Hamdan Z Hamdan, MBBS, MSc | Al-Neelain University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jaber abo aliz | Recruiting | Khartoum | Khartoum State | 1111 | Sudan |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D001205 | Ascorbic Acid |
| D005905 | Glyburide |
| ID | Term |
|---|---|
| D013400 | Sugar Acids |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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| glyburide | Drug | this group receiving glyburide 5 mg alone |
|
| D004700 | Endocrine System Diseases |
| D006880 |
| Hydroxy Acids |
| D002241 | Carbohydrates |
| D013453 | Sulfonylurea Compounds |
| D014508 | Urea |
| D000577 | Amides |
| D013450 | Sulfones |
| D013457 | Sulfur Compounds |