Vitamin C as an Adjunct in Periodontal Treatment in Type 2 Diabetes Mellitus Patients

The Effect of Vitamin C as an Adjunct in Periodontal Treatment in Uncontrolled Type 2 Diabetes Mellitus Patients

Periodontitis patients with uncontrolled type 2 diabetes mellitus will receive non-surgical periodontal treatment and then be supplemented with daily 500 mg vitamin C (test group) or placebo (control group) for 2 months. Clinical parameters will be retrieved at baseline, at the end of week 4 and at the end of week 8.

Inclusion Criteria:

• uncontrolled type 2 diabetes mellitus
• periodontitis

Exclusion Criteria:

• complications from diabetes mellitus, e.g., renal insufficiency
• receive insulin
• diseases that interfere with wound healing, e.g., HIV
• receive one of the followings: tetracycline, acetaminophen, NSAID, warfarin, aluminum-containing antacids, barbiturates, phenobarbital, pentobarbital, secobarbital, hormone replacement therapy, chemotherapeutic drug, protease inhibitor
• receive other vitamins or antibiotics within 6 months
• smoking
• pregnancy