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| Name | Class |
|---|---|
| Hass Avocado Board | OTHER |
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The purpose of this study is to examine the effect of incorporating avocados in meals on post-ingestion glycemic index, insulin response, sensations of satiety and on appetite-related gastrointestinal peptide and hormone release. Also the effect of consuming avocado containing meals on the caloric intake of participants in subsequent eating episodes will be explored.
Each subject will participate in one intervention for one day, wait one or two weeks, come for another intervention, wait one or two weeks and come for a final intervention- three in total. Participants will be randomly assigned to one of six treatment sequences. Postprandial response to the control and two avocado-containing test meals will be assessed and compared using a 3 x 3 single blind cross-over design. The Subjects will be between 25 and 60 years old, female or male, with a BMI of 23 to 32, stable weight, no sports involvement, non-smoking and not dependent on caffeine. Thirty subjects will be recruited.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | While on the control arm subjects will be given a meal with no avocado. | |
| Avocado supplement | Active Comparator | While on the avocado supplement arm subjects will be given a meal in which a given amount of calories will be replaced by calories contributed by avocados. |
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| Avocado included | Active Comparator | While on the avocado included arm subjects will be given a meal in which the calories of avocado will be added to the calories of the control meal. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Avocado supplement | Dietary Supplement | Calories from avocados replace calories of the control lunch |
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| Measure | Description | Time Frame |
|---|---|---|
| Satiety | The effect that consumption of avocados has on feelings of fullness and the quantity of food consumed in a subsequent eating episode | 12 hours |
| Measure | Description | Time Frame |
|---|---|---|
| post-ingestion glycemic index | Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. The glycemic index will be analyzed. | 3 hours |
| insulin response |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Joan Sabaté, MD, DrPH | Loma Linda University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Loma Linda University, Department of Nutrition | Loma Linda | California | 92350 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24279738 | Result | Wien M, Haddad E, Oda K, Sabate J. A randomized 3x3 crossover study to evaluate the effect of Hass avocado intake on post-ingestive satiety, glucose and insulin levels, and subsequent energy intake in overweight adults. Nutr J. 2013 Nov 27;12:155. doi: 10.1186/1475-2891-12-155. |
| Label | URL |
|---|---|
| Publication of study results | View source |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Avocado included | Dietary Supplement | Calories from avocados will be added to calories from the control lunch |
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Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. Insulin response will be analyzed.
| 3 hours |
| appetite-related gastrointestinal peptide and hormone release | Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. Gastrointestinal peptide and hormones will be analyzed. | 3 hours |