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This phase II trial is studying cisplatin or nedaplatin combine with IMRT to evaluate which one is better efficacy and security in nasopharyngeal carcinoma.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cisplatin | Active Comparator | cisplatin combine with IMRT |
|
| Nedaplatin | Experimental | Nedaplatin combine with IMRT |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cisplatin | Drug | 40mg/m2/w |
| |
| Nedaplatin |
| Measure | Description | Time Frame |
|---|---|---|
| locoregionally control rate | 3 months after treatment | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Survival | 1 year Progress Free Survival,Disease Free Survival,3 years and 5 years Over All Survival,Safety | 1,3,5 years |
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Inclusion Criteria:
Age≥18,T1-2aN1-3;T2-4NxNPC,VEGFR+,++,KPS>70,Life expectancy≥6 months, No uncontrolled hypertension,cardiac failure,diabetes,lunacy
Exclusion Criteria:
Distant metastasis, recurrent disease
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhenzhou Yang, Dr. | Contact | 86(23)68757182 | yangzhenzhou@sohu.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Daping Hospital | Chongqing | China |
|
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| Drug |
40mg/m2/w |
|
| ID | Term |
|---|---|
| D000077274 | Nasopharyngeal Carcinoma |
| ID | Term |
|---|---|
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009303 | Nasopharyngeal Neoplasms |
| D010610 | Pharyngeal Neoplasms |
| D010039 | Otorhinolaryngologic Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D009371 | Neoplasms by Site |
| D009302 | Nasopharyngeal Diseases |
| D010608 | Pharyngeal Diseases |
| D009057 | Stomatognathic Diseases |
| D010038 | Otorhinolaryngologic Diseases |
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| ID | Term |
|---|---|
| D002945 | Cisplatin |
| C053989 | nedaplatin |
| ID | Term |
|---|---|
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017672 | Nitrogen Compounds |
| D017671 | Platinum Compounds |
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