Nasopharyngeal carcinoma has high incidence in the southern China, especially in Guangdong Province. In the world, the standardized morbidity has reached 30/10 million in men while in women, about 13/10 million. At present, the incidence of nasopharyngeal carcinoma in China accounted for more than 80% of the world. The cancer-related deaths is in the eighth, which is a serious threat to our people's health and life. A recent multi-center phase II study of stage II nasopharyngeal carcinoma showed that: compared with Intensity Modulation Radiotherapy (IMRT) plus cisplatin, the 3 year local control rate, regional control rate, distant metastasis-free survival rate and disease-specific survival rate of IMRT were similar, but the side effects of radiotherapy alone group were lower.

Based on the results of the phase II clinical study, the investigators designed this phase III clinical study, with the aim to compared the efficacy and toxicity of these two treatment programs. And finally to provide sufficient evidence for the treatment of stage II nasopharyngeal carcinoma.

Inclusion Criteria:

• The sex of the subject is not limited, the age is from 18 to 70 years old;
• Histologically proven nasopharyngeal squamous cell carcinoma, World Health Organization (WHO) II-III type;
• Union Internationale Contre le Cancer(UICC) stage 9 clinical stage II patients；
• Karnofsky score ≥ 80 points;
• No evidence of distant metastasis;
• Having an nasopharyngeal MRI before treatment ,which can measure the size of the tumor in order to analyze the effect.

Exclusion Criteria:

• The subject had previously suffered from other malignancies (except non-melanotic skin cancer or cervical carcinoma in situ);
• Previously received immunotherapy;
• Previously received chemotherapy;
• Previously received radiation therapy;
• Patients who had previously undergone surgical treatment for head and neck tumors (excluding cervical lymphadenectomy);
• Evidence of distant metastases or other malignancies at the same time.