Perioperative Administration of Pregabalin in Patients Undergoing Arthroscopic Anterior Cruciate Ligament Reconstruction

Perioperative Administration of Pregabalin in Patients Undergoing Arthroscopic Anterior Cruciate Ligament Reconstruction: Does it Help to Relieve Postoperative Pain?

To prove pregabalin's efficacy and safety in Thai patients scheduled for arthroscopic ACL reconstruction

Only eligible patients with willingness to join this study are included. Eligible patients are those aged 18-65 years of either sex, American Society of Anesthesiologists (ASA) physical status I & II, and body mass index (BMI) between 16-35. The exclusion criteria are patients who are allergic to pregabalin, with impaired hepatic and renal functions, alcohol or substance abuse, chronic pain (except pain in the knee joint) or daily intake of analgesics, uncontrolled medical disease (hypertension and diabetes mellitus) and inability to operate patient-controlled analgesia (PCA) device.

Data analysis

• Student t-test for continuous data with normal distribution
• Mann-Whitney U test for continuous data with non-normal distribution
• Chi-square test for categorical data

Inclusion Criteria:

• Eligible patients are those aged 18-65 years of either sex,
• American Society of Anesthesiologists (ASA) physical status I & II, and body mass index (BMI) between 16-35.

Exclusion Criteria:

• patients who are allergic to pregabalin,
• impaired hepatic and renal functions,
• alcohol or substance abuse,
• chronic pain (except pain in the knee joint) or daily intake of analgesics, uncontrolled medical disease (hypertension and diabetes mellitus)
• inability to operate patient-controlled analgesia (PCA) device