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The purpose of this study is to see if chewing sugarless chewing gum alters the time it takes for a capsule endoscopy to travel through the stomach and small bowel, and to see if more/less capsule endoscopes reach the large bowel.
The subjects will include patients already referred to us for a capsule endoscopy (CE) in this unit. We have calculated how many patients we need from small bowel transit times from the last 100 patients who had a CE at our centre. We will include 122. These will be randomly divided into two groups. The patients (chew chewing gum) and the controls (do not chew chewing gum).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1. | Active Comparator | The subject group will chew sugarless chewing gum for a specific amount of time while undergoing capsule endoscopy. |
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| 2. | Placebo Comparator | The control group will not chew chewing gum while undergoing capsule endoscopy. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Trident sugarless chewing gum. | Other | Patients will be randomly divided into 2 groups, one subject group (these chew gum) and one control group (these do not chew gum). The subjects will have to chew Trident sugarless chewing gum for 20-30 minutes every 2 hours, all together 4 times at t=0 h, t=2, t=4 and t=6 h. |
| Measure | Description | Time Frame |
|---|---|---|
| Small bowel transit time | 6 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Gastric transit time, cecal completion rate | 6 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Robert A. Enns, Dr. | University of British Columbia | Principal Investigator |
| Eric Lam, Dr. | University of British Columbia | Study Director |
| Jennifer Telford, Dr. | University of British Columbia | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St. Paul's Hospital | Vancouver | British Columbia | V6Z 2K5 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24112594 | Derived | Ou G, Svarta S, Chan C, Galorport C, Qian H, Enns R. The effect of chewing gum on small-bowel transit time in capsule endoscopy: a prospective, randomized trial. Gastrointest Endosc. 2014 Apr;79(4):630-6. doi: 10.1016/j.gie.2013.08.038. Epub 2013 Oct 7. |
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| One control group (these do not chew gum). | Other | The control group will not chew chewing gum while undergoing capsule endoscopy |
|