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The aim of the study is to investigate the relationship between aging and morphological changes in the lung. 120 consecutive healthy volunteers over 60 years will be enrolled for this trial.
Chest multidetector CT without injection and spirometry data will be obtained from a multicentric sample of individuals between 60 and 95 years of ageExclusion criteria were current smoking, history of smoking within the past 10 years, any known chronic or acute pulmonary disease. Individuals treated with Amiodarone, Bleomycin or methotrexate were excludedOutcome
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 60 - 70 years old | Experimental | EFR and TDM |
|
| 71 - 80 years old | Experimental | EFR and TDM |
|
| 81 - 95 years old | Experimental | EFR and TDM |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| EFR and TDM | Other | EFR : Pulmonary function test TDM : tomodensitometry |
|
| Measure | Description | Time Frame |
|---|---|---|
| Bronchial wall thickness | Bronchial wall thickness and remodeling associated with aging | 1 day |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| BOMMART Sebastien, MD | University Montpellier Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Montpellier Hospital | Montpellier | 34295 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24581147 | Result | Bommart S, Marin G, Bourdin A, Molinari N, Klein F, Hayot M, Vachier I, Chanez P, Mercier J, Vernhet-Kovacsik H. Relationship between CT air trapping criteria and lung function in small airway impairment quantification. BMC Pulm Med. 2014 Feb 28;14:29. doi: 10.1186/1471-2466-14-29. |
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| ID | Term |
|---|---|
| D056151 | Airway Remodeling |
| ID | Term |
|---|---|
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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