Effect of Ageing on Airway Remodeling

Study of Bronchoalveolar Lung Remodeling in Subjects From 60 Years Free of Progressive Lung Disease: Structure-function Analysis

The aim of the study is to investigate the relationship between aging and morphological changes in the lung. 120 consecutive healthy volunteers over 60 years will be enrolled for this trial.

Chest multidetector CT without injection and spirometry data will be obtained from a multicentric sample of individuals between 60 and 95 years of ageExclusion criteria were current smoking, history of smoking within the past 10 years, any known chronic or acute pulmonary disease. Individuals treated with Amiodarone, Bleomycin or methotrexate were excludedOutcome

Inclusion Criteria:

• People from 60 to 95 years old free from chest disease or history of chest disease

Exclusion Criteria:

• Chronic cough
• Dyspnea
• Sinonasal or chest infection during enrollment
• Myocardial infarction.
• Current smoker or past smoker with more than 10 pack year intoxication