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| ID | Type | Description | Link |
|---|---|---|---|
| 2013-A01405-40 | Other Identifier | RCB number |
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COPD is characterized by exagerated decline FEV1 related to obstructive non reversible airflow. This could be the consequence of structural changes and inflammatory pattern of the bronchial wall. Lesions could lead to normal but also abnormal remodeling specially in COPD including a decrease in Club cells number and function.There is no treatment actually available targeted to a normal repair of the epithelium. The objective of this work is to identify potential targets for reprograming bronchial epithelial cells I order to achieve a good repair.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Heathy volunteers, smokers and COPD | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| In vitro experiments on bronchial epithelial cells | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Full recovery one day after injury (yes / no) proportion of cells showing the repair, remodeling or regeneration of the epithelium (ciliated cells, mucus cells, Clara cells) in culture in air-liquid interface in the three groups | The study will be judged on the proportion of cells showing the repair, remodeling or regeneration of the epithelium (ciliated cells, mucus cells, Clara cells) in culture in air-liquid interface in the three groups. | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of apoptosis and inflammation (IL8) | Determine the molecular mechanisms and deleterious cell leading to poor repair of the epithelium in patients with COPD | 24 months |
| Measure the effect of the CC10 protein secreted by Clara cells on the repair of the bronchial epithelium. |
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Inclusion Criteria:
COPD - Smokers or ex smokers > 30p/yr
Smokers - Smokers or ex smokers > 30p/yr
Controls - age superior or equal to 18
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| BOURDIN Aranud, MD, PhD | University Hospital, Montpellier | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pneumology Department | Montpellier | 30295 | France |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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Measuring the reprogramming of the epithelium of COPD patients to a control-type epithelium |
| 24 months |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |