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| Name | Class |
|---|---|
| German Federal Ministry of Education and Research | OTHER_GOV |
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The researchers will investigate whether exercise could provide positive effects on general brain functions in elderly people with impaired glucose tolerance.
The age-related degradation of cognitive functions even to the point of neurodegenerative disorders such as Alzheimer's disease are a growing public-health concern with devastating effects.
Referring to animal data, empirical studies, and pilot human trials, exercise should improve cognitive functions such as learning and memory. To test this hypothesis, the researchers study general brain functions in elderly subjects (50-80 years old) with impaired glucose tolerance during a short term exercise program.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise | Experimental |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Behavioral | 6 months of aerobic exercise |
|
| Measure | Description | Time Frame |
|---|---|---|
| Auditory Verbal Learning Task | Prior to intervention and after 6 months of intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Functional/Structural brain changes | Prior to intervention and after 6 months of intervention | |
| Plasma biomarkers | Prior to intervention and after 6 months of intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Agnes Flöel, MD, Prof. | Charité University Berlin | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Neurology, Charité Universitätsmedizin | Berlin | State of Berlin | Germany |
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| ID | Term |
|---|---|
| D018149 | Glucose Intolerance |
| D009043 | Motor Activity |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D006943 | Hyperglycemia |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| D001519 | Behavior |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |