Effect of Diltiazem on Pharmacokinetics of BMS-914392

Effect of Diltiazem on the Pharmacokinetics of BMS-914392 and on Heart Rate After Single-dose Administration of BMS-914392 in Healthy Subjects

The purpose of this study is to assess the effects of diltiazem on the pharmacokinetics of single-dose BMS-914392 in healthy subjects.

Protocol designed to evaluate the potential for a drug-drug interaction

Inclusion Criteria:

• Healthy subjects as determined by no clinically significant deviation from normal in medical history, physical examination, ECGs, and clinical laboratory determinations
• Women of childbearing potential (WOCBP) and men must be using an acceptable method of contraception to avoid pregnancy

Exclusion Criteria:

• Current or recent (within 3 months of study drug administration) gastrointestinal disease
• Current or history of neurological diseases or psychiatric disorders and cardiovascular diseases