A Clinical Study of MK-4318 and Diltiazem in Healthy People (MK-4318-003)

A Two-period Study to Evaluate the Effects of Multiple Oral Doses of Diltiazem on the Single-dose Pharmacokinetics of MK-4318 in Healthy Participants

The goal of this study is to learn what happens to MK-4318 in a person's body over time. Researchers will compare what happens to levels of MK-4318 in people's blood when it is taken with and without diltiazem. Researchers also want to learn about the safety of MK-4318 taken with and without diltiazem and if people tolerate them.

Inclusion Criteria

The main inclusion criteria include but are not limited to the following:

• Is in good health based on medical history and physical examination
• Has a body mass index >18 and ≤32 kg/m^2, inclusive

Exclusion Criteria

The main exclusion criteria include but are not limited to the following:

• Has a history of clinically significant endocrine, gastrointestinal, cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke and chronic seizures) abnormalities or diseases
• Has a history of cardiac arrythmia or recurrent unexplained syncopal events