Effect of BMS-914392 on Pharmacokinetics of Metoprolol

Effect of BMS-914392 on the Pharmacokinetics of Metoprolol and on Heart Rate After Co-administration of BMS-914392 and Metoprolol in Healthy Subjects

The purpose of the study is to assess the effects of BMS-914392 administration on the pharmacokinetics of a single-dose of metoprolol in healthy subjects.

Protocol designed to evaluate the potential for a drug-drug-interaction

Inclusion Criteria:

• Healthy subjects as determined by no clinically significant deviation from normal in medical history, physical examination, ECGs, and clinical laboratory determinations.
• Subjects genotyped as Intermediate, Extensive or Ultra-rapid CYP2D6 metabolizers
• Women of childbearing potential (WOCBP) and men must be using an acceptable method of contraception to avoid pregnancy

Exclusion Criteria:

• Any significant acute or chronic medical illness.
• Current or recent (within 3 months of study drug administration) gastrointestinal disease.
• Current or history of neurological diseases or psychiatric disorders, cardiovascular diseases, and bronchospastic diseases.
• CYP2D6 poor metabolizers based on genotype