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| ID | Type | Description | Link |
|---|---|---|---|
| 2007-A01319-44 | Other Identifier | French Health Products Savety Agency |
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Obesity is now becoming significantly prevalent of an environment characterized by easily available calorics foods combined with sedentary lifestyles. Moreover, it has been demonstrated that obesity is associated with metabolic complications such as disturbed adipocytokines, hormones secreted by adipose tissue. Given these observations, the purpose of this study is to assess the effects of a lifestyle intervention focused on various physical activities and nutrition education on adipocytokines hormones, in severely obese teenagers.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| obesity lifestyle intervention | Behavioral | physical activity 5 times per week + nutrition education |
| Measure | Description | Time Frame |
|---|---|---|
| Adipocytokines (leptin, adiponectin, ghrelin, PAI-1, resistin), based on subject's arterialized capillary blood samples. | during a lifestyle intervention of 9 months |
| Measure | Description | Time Frame |
|---|---|---|
| Body weight, body mass index, waist and hip circumference | during a lifestyle intervention of 9 months | |
| Body composition, calculated by a multifrequency bioelectric impedance | during a lifestyle intervention of 9 months |
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Inclusion Criteria:
Exclusion criteria:
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obese teenagers
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| Name | Affiliation | Role |
|---|---|---|
| Nhu Uyen Nguyen, MD, PhD | Centre Hospitalier Universitaire de Besancon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Universitaire | Besançon | 25030 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22574715 | Derived | Gueugnon C, Mougin F, Simon-Rigaud ML, Regnard J, Negre V, Dumoulin G. Effects of an in-patient treatment program based on regular exercise and a balanced diet on high molecular weight adiponectin, resistin levels, and insulin resistance in adolescents with severe obesity. Appl Physiol Nutr Metab. 2012 Aug;37(4):672-9. doi: 10.1139/h2012-045. Epub 2012 May 11. | |
| 21909986 |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D063766 | Pediatric Obesity |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Glycemia and lipids profile, based on subject's arterialized capillary blood samples analysis. | during a lifestyle intervention of 9 months |
| Insulin resistance, calculated according to the formula of homeostasis model assessment | during a lifestyle intervention of 9 months |
| Systolic and diastolic blood pressure, measured in millimeters of mercury at the level of the left brachial artery, using an automatic blood pressure monitor. | during a lifestyle intervention of 9 months |
| Gueugnon C, Mougin F, Nguyen NU, Bouhaddi M, Nicolet-Guenat M, Dumoulin G. Ghrelin and PYY levels in adolescents with severe obesity: effects of weight loss induced by long-term exercise training and modified food habits. Eur J Appl Physiol. 2012 May;112(5):1797-805. doi: 10.1007/s00421-011-2154-2. Epub 2011 Sep 11. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |