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| ID | Type | Description | Link |
|---|---|---|---|
| DMI01425 | Other Grant/Funding Number | Dairy Management Inc. |
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| Name | Class |
|---|---|
| Dairy Management Inc. | INDUSTRY |
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The objective of this project is to determine the effect of 9 months of progressive resistance training with daily whey protein supplements on the body composition (changes in muscle and fat) in young adults. The investigators hypothesize that those individuals who receive whey protein supplements will have larger gains in muscle and larger losses of fat tissue in response to resistance training compared to those who receive supplements of soy or carbohydrate.
Healthy men and women will be recruited to participate in 9 months of supervised resistance training (3 days/wk) and will be randomized to one of three daily supplement groups: Whey protein, soy protein, or carbohydrate control. Body weight, muscular strength and endurance, and resting blood pressure will be assessed at baseline, 3, 6 and 9 months. Body composition will be assessed at baseline, 3, 5, 7, and 9 months. A sub-sample (N = 17 per group, assessed at baseline and 9 months) will be randomly selected for muscle samples of the upper leg to determine changes in the size of muscle fibers, and chemical factors associated with muscle growth. Blood samples will be obtained from sub-sample participants to assess changes in glucose and fat metabolism, as well as other chemicals likely to promote or inhibit muscle growth. We will also assess changes in daily energy expenditure and the use of fuel to produce energy (carbohydrate, fat, protein) that may result from the intervention. We hypothesize that those individuals who receive whey protein supplements will have larger gains in muscle and larger losses of fat tissue in response to resistance training compared to those who receive supplements of soy or carbohydrate.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Whey protein supplementation | Experimental | Daily whey protein supplementation |
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| Soy Protein supplementation | Experimental | Daily soy protein supplementation |
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| Placebo | Experimental | Daily carbohydrate placebo supplementation |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Whey Protein supplement | Dietary Supplement | 40 g/day of whey protein will be consumed in 2 doses for 9 months (Study duration) |
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| Measure | Description | Time Frame |
|---|---|---|
| Body Composition | Changes in body composition will be evaluated by measuring the change in percent body fat, total fat mass, and total lean mass by DEXA. | 9 months |
| Measure | Description | Time Frame |
|---|---|---|
| 24 hour energy expenditure and substrate oxidation | 24hr energy expenditure and substrate oxidation will be measured by whole room indirect calorimetry | 9 months |
| Muscular strength and endurance |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Richard A. Washburn, Ph.D. | University of Kansas | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Energy Balance Lab, The University of Kansas | Lawrence | Kansas | 66045 | United States |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Soy Protein Supplement | Dietary Supplement | 40 g/day of soy protein will be consumed in 2 doses for 9 months (Study duration) |
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| Carbohydrate supplement | Dietary Supplement | 40 g/day of maltodextrin will be consumed in 2 doses for 9 months (Study duration) |
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One rep max strength will be measured on the chest and leg press.
| 9 months |
| Resting Metabolic Rate | Resting metabolic rate as measured by indirect calorimetry as kcal/day will be evaluated. Also, substrate oxidation (fat and carbohydrate oxidation) will be evaluated. | 9 months |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |