The purpose of this study is to identify the influence of resistance and aerobic exercise with different nutritional supplements in middle-aged men and women on various physiological measures. Throughout the study, the investigators examine body composition, body weight, food intake, fitness level, metabolism, and blood hormones.

Inclusion Criteria:

• men and women age 35-65 yr
• body weight <300 lbs (136 kg)
• body mass index between 28 kg/m2 and 35 kg/m2
• fasting glucose <110 mg/dL
• blood pressure <160/100 mm Hg
• plasma total cholesterol <260 mg/dL
• LDL-cholesterol <160 mg/dL
• triacylglycerol <400 mg/dL
• not currently or previously following a weight loss diet or other special/non-balanced diet (in the past 6 months)
• <1 hour/week of habitual aerobic exercise training and no resistance
• exercise training (in the past 6 months)

Exclusion Criteria:

• men and women age < 35 yr or >65 yr
• body weight >300 lbs (136 kg)
• body mass index between <28 kg/m2 or >35 kg/m2
• fasting glucose >110 mg/dL
• blood pressure >160/100 mm Hg
• plasma total cholesterol >260 mg/dL
• LDL-cholesterol >160 mg/dL
• triacylglycerol >400 mg/dL
• currently or previously following a weight loss diet or other special/non- balanced diet (in the past 6 months)