The aim of the study is to perform a prospective, multicenter research comparing capsule endoscopy with the video colonoscopy in the detection of the adenomatous polyps and cancer specifically in a high risk population (sensibility, specificity, NPV, PPV and diagnostic accuracy). The investigators will used the Pillcam II™ colon capsule (second generation) and a high resolution colonoscope (with high definition). Both procedures will be perform in the same day with an adapted bowel preparation.

Inclusion Criteria:

• Age > 18 years old
• Patient with 40 years old and first degree relative affected by colo rectal cancer at age ≥ 60 ans
• Patient with 40 years old or ten years before the age at affected disease in case or first deree relative colo rectal cancer before 60 years old.
• Fecal occult blood test positive
• Personal history of adenomatous polyps
• Personnal history of acromegaly
• Patient with social insurance
• Persons already participating in another clinical trial..
• Signature of informed consent

Exclusion Criteria:

• Pregnancy or breast feeding woman
• Déficience mentale du sujet rendant sa participation à l'essai impossible
• Pacemaker or all electronic devices implanted
• Patient with swallowing disorder, or digestive stricture know or suspected by the investigator
• Previous history of intestinal surgery, radiotherapy or inflammatory bowel disease
• Previous history of polyadenomatous congenital disease, Lynch syndrome
• Intolerance with dompéridon and/or bisacodyl
• Intolerance with oral intake of NaP, polyethylen glycol (PEG) or macrogol
• Colonoscopy contre indication for anesthesiologic reasons