Effect of Tranexamic Acid on Prevention of Recurrence of Hemoptysis

Effect of Tranexamic Acid on Prevention of Recurrence of Hemoptysis: Multicenter, Prospective, Randomized, Double-blind Phase 3 Trial

Hemoptysis is one of the serious complication of many pulmonary diseases. Upto now, there is no proven medical treatment in recurrence of hemoptysis. The investigators will conduct a randomized, placebo controlled trial of tranexamic acid, which can reduce the recurrence of hemoptysis.

Inclusion Criteria:

• age: >=20 and <=75
• ER visit or admission for hemoptysis
• no evidence of hemoptysis on screening

Exclusion Criteria:

• anticoagulation treatment
• Cr >= 2.0 mg/dL or urinary protein >= 2+ or who received renal replacement treatment
• hepatic failure: total bilirubin >= 1.5 mg/dL or AST or ALT >= 1.5 of upper normal limit level
• hypersensitivity to tranexamic acid
• pregnant woman
• fertile female who don't use contraception