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The purpose of the study is to characterise the absorption, distribution, metabolism and excretion (ADME) of a single oral dose of [14C]AZD9668.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | [C14]AZD9668 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| [C14]AZD9668 | Drug | Oral Solution 60 mg Single Dose |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of radioactive dose recovered in urine and faeces and total balance | Samples collected prior to treatment, during treatment and follow-up for a maximum of 14 days. | |
| Concentration of total radioactivity in blood and plasma | Samples collected prior to treatment, during treatment and follow-up for a maximum of 14 days. | |
| Plasma concentrations of AZD9668 | Samples collected prior to treatment, during treatment and follow-up for a maximum of 14 days. | |
| Metabolite profiling and identification in plasma and excreta | Samples collected prior to treatment, during treatment and follow-up for a maximum of 14 days. | |
| PK of AZD9668 (Cmax, tmax, t½, AUC, CL/F, Vz/F, MRT, fe, Ae, CLR ) | Samples collected prior to treatment, during treatment and follow-up for a maximum of 14 days. |
| Measure | Description | Time Frame |
|---|---|---|
| Adverse Events | Adverse events collected prior to treatment and after treatment including follow up. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Chris O'Brien | AstraZeneca R&D, Wilmington | Study Director |
| Tim Mant, Professor | Quintiles Drug Research Unit, United Kingdom | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Site | London | United Kingdom |
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