Future development of AZD1236 is currently under review by the project team and no new studies will be started until this review is completed.

The purpose of this study is to characterise the metabolism, excretion and pharmacokinetics of a single oral dose of [14C] AZD1236 in healthy male subjects.

Inclusion Criteria:

• Healthy volunteers
• Non-smokers

Exclusion Criteria:

• Subjects who are exposed to radiation exposure as part of their occupation
• Subjects exposed to radiation levels above background of >5 mSv in last year, >10 mSv over last 5 years or a cumulative total of > 1 mSv per year of life
• A history or presence of conditions known to interfere with the absorption, distribution, metabolism or excretion for drugs eg. haematological, gastrointestinal, hepatic or renal disease etc