Open Label, Healthy Volunteers, ADME Study With Single Oral Administration of [14C] AZD5069

A Phase I, Open-Label Study to Characterise the Absorption, Distribution, Metabolism and Excretion Following a Single Oral Dose of [14C]AZD5069 in Healthy Male Volunteers

This is a phase I, open label, healthy volunteers, ADME study with single oral administration of [14C] AZD5069.

Inclusion Criteria:

• Have a body mass index (BMI) of ≥18 and ≤30 kg/m2 and weight of ≥50 kg and ≤100 kg.
• Regular daily bowel movements (ie, production of at least 1 stool per day).
• Non-smoker or ex-smoker who has not used tobacco or nicotine products for ≥6 months prior to Visit 1
• Healthy Male volunteers aged 50 and over

Exclusion Criteria:

• Healthy volunteers who have been exposed to radiation levels above background (eg, through X-ray examination) of >5 mSv in the last year, >10 mSv in the last 5 years, or a cumulative total of >1 mSv per year of life
• Participation in any prior radiolabelled study within last 5 years
• History of alcohol abuse or excessive intake of alcohol as judged by the investigator.