Relation Between Aldosterone and Cardiac Remodeling After Myocardial Infarction

Multiparametric Study of Cardiac Remodeling After Myocardial Infarction Revascularized in Acute Phase : Relation With the Serum Concentrations in Aldosterone

This study aims to determine whether aldosterone blood levels are predictive of cardiac remodeling at 6 months following myocardial infarction with ST elevation (STEMI), independently of conventional predictive factors (size of myocardial infarction, age, hypertension, etc.) in revascularized patients during the acute phase of MI.

After myocardial infarction, the evolution toward cardiac failure is generally linked to a progressive worsening of cardiac dysfunction and remodeling. Cardiac remodeling is largely the consequence of myocardial injury due to myocardial infarction, although other parameters including age, arterial hypertension, etc. may also represent important predictors. Aldosterone blood levels measured within the first hours of admission for myocardial infarction is associated with increased rates of adverse outcomes. Aldosterone acts on wound healing and fibrosis processes in the myocardium as well as on systemic volemia.

Inclusion Criteria:

• Man or woman hospitalized for a first myocardial infarction with known shift of the segment ST revascularized in acute phase by primary angioplasty and dated less than 4 days
• Patient presenting a stable clinical state
• Patient presenting a regular sinusal cardiac rhythm
• Patient having an age ≥ 18 years

Exclusion Criteria:

• Counter-indication with examination MRI
• Severe claustrophobia
• Antecedent of over-sensitiveness to gadolinium salts
• Nonischaemic Cardiopathy
• Cardiac surgery planed in the 6 months
• Women into old to procreate without effective contraception