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Following myocardial infarction, female individuals demonstrate a poorer prognosis, characterized by elevated rates of mortality and heart failure. A primary hypothesis suggests unfavorable cardiac remodeling in women. This remodeling, defined as alterations in cardiac size and shape post-infarction, necessitates repeated non-invasive imaging for study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| case control registry | Other | left ventricular remodeling measurement with cardiac echography |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cardiac imaging to assess left ventricular volumes and function | Diagnostic Test | non-invasive cardiac imaging (echocardiography and MRI) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Asses left ventricular remodeling disparities between genders | The primary outcome measure will be the occurrence of left ventricular remodeling (defined as a change in ventricular volume of more than 10% during follow-up) measured with cardiac imaging (echocardiography and MRI) | baseline; 3 months and 1 year after myocardial infarction onset |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate the evolution of remodeling at Month 3 | Changes in ventricular volumes between acute phase and 3 months measured with cardiac imaging (echocardiography and MRI) | 3 months |
| Assess remodeling changes between inclusion and Month 12 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| LOIC BIERE, PHD | Contact | 02 41 35 36 37 | +33 | LoBiere@chu-angers.fr |
| VIVIANE CASSISA | Contact | 02 41 35 36 37 | +33 | DRCI-Promotion-Interne@chu-angers.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital, Angers | Recruiting | Angers | France |
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| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| D020257 | Ventricular Remodeling |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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Changes in ventricular volumes between acute phase and 1 year measured with cardiac imaging (echocardiography and MRI)
| 1 year |
| Assess the prevalence of comorbidities and their impact on the effect on the outcome: post-infarction cardiac remodeling with gender (cardiovascular risk factors, renal function, hepatic functionperipheral artery disease, way of life) | renal function: uremia and creatinine levels, combined with an assessment of the protein-to-creatinine ratio in urine samples, and a cyto-bacteriological examination of urine to detect hematuria; hepatic function: The Fibroscan® is a device that enables a non-invasive and efficient assessment of liver fibrosis and steatosis within minutes at the patient's bedside, providing an immediate result displayed on the device screen; peripheral artery disease: Doppler echocardiography of the supra-aortic trunks; way of life : dietetary, stress and physical activity scores common CV risk factors: prior history of hypertension, hypercholesterolaemia, tobacco use, diabetes | 3 months and 1 year |
| Explore prognostic disparities between men and women. | Occurrence of complications and cardiovascular events (cardiovascular death, heart failure, stroke, or reinfarction) | yearly, up to 10 years |
| Evaluate lifestyle habits up to 10 years: outcome anxiety/depression | Anxiety/Depression (A.D) score: 2 scales from 0 to 21, the greatest the more prone to either anxiety or depression | yearly, up to 10 years |
| Evaluate lifestyle habits up to 10 years: outcome diet score | Mediteranean diet score (MED): from 0 to 14, the greatest the more relevant for mediteranean diet | yearly, up to 10 years |
| Evaluate lifestyle habits up to 10 years: outcome physical activity | physical activity: lipid research clinics (LRC); 2 scales from 1 to 5, the greatest the less active | yearly, up to 10 years |
| Assess the risk of remodeling based on specific parameters in female subjects: presence of endometriosis | presence or absence of endometriosis | baseline |
| Assess the risk of remodeling based on specific parameters in female subjects: presence of polycystic ovary | presence or absence of polycystic ovary | baseline |
| Assess the risk of remodeling based on specific parameters in female subjects: presence of uterine fibroma | presence or absence of uterine fibroma | baseline |
| Assess the risk of remodeling based on specific parameters in female subjects: presence of hormonal therapy | presence or absence of hormonal therapy | baseline |
| Assess the risk of remodeling based on specific parameters in female subjects: date of first period | date of first period | baseline |
| Assess the risk of remodeling based on specific parameters in female subjects: pregnancy | number of pregnancy | baseline |
| Assess the risk of remodeling based on specific parameters in female subjects: children | number of children | baseline |
| Assess the risk of remodeling based on specific parameters in female subjects: obstetrical event | absence or presence of obstetrical events (hypertension, diabete, microsomia and macrosomia) | baseline |
| Assess the risk of remodeling based on specific parameters in female subjects: menopause | absence or presence of menopause | baseline |
| D007238 |
| Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D020763 | Pathological Conditions, Anatomical |