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| Name | Class |
|---|---|
| University of British Columbia | OTHER |
| InovoBiologic Inc. | INDUSTRY |
The objective of the study is to compare subjective appetite ratings and after-meal and 24 hour blood glucose levels within overweight and obese female subjects consuming either a standardized 3 day low calorie diet supplemented with a viscous fibre known as PGX (treatment) or a rice flour (placebo control). Each treatment phase will be 3 days in length and separated by 3 week washout phase, so subjects will also be acting as their own control. Subjects will be randomized to either start with the low calorie diet with PGX or the low calorie diet supplemented with rice flour. We hypothesize that the 3 day LCD with PGX will elicit an improved appetite score compared to the 3 day LCD supplemented with the rice flour placebo control.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PolyGlycopleX (PGX) | Experimental | 5 grams of PGX 3 times per day with each main meal (breakfast, lunch and dinner) |
|
| Rice flour | Placebo Comparator | 5 grams of rice flour 3 times per day at each main meal (breakfast, lunch and dinner) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PolyGlycopleX (PGX) | Dietary Supplement | powder, 5 grams, 3 times per day at each main meal (breakfast, lunch and dinner) for a total of 3 days |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in the ratings of the variables in the Appetite Visual Analog Scale and the overall Appetite Score. | 3 days |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in 2-hour postprandial areas under the curve (AUC) and 24 hour blood glucose (CGMS) profiles. | 3 days |
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Inclusion Criteria:
- BMI 25-35 Kg/m2
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michael Lyon, MD | University of British Columbia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Canadian Centre for Functional Medicine | Coquitlam | British Columbia | V3K6Y2 | Canada | ||
| Canadian Center for Functional Medicine |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23154443 | Result | Kacinik V, Lyon M, Purnama M, Reimer RA, Gahler R, Green TJ, Wood S. Effect of PGX, a novel functional fibre supplement, on subjective ratings of appetite in overweight and obese women consuming a 3-day structured, low-calorie diet. Nutr Diabetes. 2011 Dec 12;1(12):e22. doi: 10.1038/nutd.2011.18. |
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| Coquitlam |
| British Columbia |
| Canada |
| ID | Term |
|---|---|
| C540519 | PolyGlycoplex |
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