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| Name | Class |
|---|---|
| InovoBiologic Inc. | INDUSTRY |
| Canadian Center for Functional Medicine | OTHER |
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Reductions of postprandial glucose levels have been demonstrated previously with the addition of a novel viscous polysaccharide (NVP) to a glucose drink and standard white bread. This study explores whether these reductions are sustained when NVP is added to a range of commonly consumed foods.
Recently, a commercial novel viscous polysaccharide (NVP)complex has been developed which is marketed in both the USA and Canada under the trade name PGX® (PolyGlycopleX) (InovoBiologic Inc, Calgary, AB, Canada). This complex consists of three viscous non starch polysaccharides which are processed using proprietary technology (EnviroSimplex®) to produce compressed granules which delays the onset of viscosity and increases palatability of the fiber when added to food. Previously, this fibre was shown to lower postprandial glucose levels in a dose responsive manner when mixed with a glucose drink and sprinkled onto a standard white bread demonstrating that the processing did not interfere with the effectiveness of the fiber. From this study the reduction in GI was calculated to be 7 units per gram of NVP when added to a solid food, however it is not known whether this relationship would be maintained when the NVP was added to a range of commonly eaten foods. This study therefore evaluates the effect of the addition or incorporation of NVP into a range of foods on postprandial glycemia and whether the reductions in glycemic index could be predicted using.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Placebo Comparator | Control White bread containing 50g available carbohydrate |
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| 2 | Placebo Comparator | White bread and milk control |
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| 3 | Placebo Comparator | Granola control |
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| 4 | Placebo Comparator | Cornflakes and milk control |
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| 5 | Placebo Comparator | White rice control |
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| 6 | Placebo Comparator | Fruit yogurt control |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PolyGlycopleX (PGX) | Dietary Supplement | 2.5 grams of PGX |
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| Measure | Description | Time Frame |
|---|---|---|
| Relative Blood glucose response of food with and without NVP | Acute blood glucose response measured at 0, 15,30,45,60,90 and 120 min |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alexandra L Jenkins, PhD, RD | Glycemic Index Laboratories, Inc | Study Director |
| Thomas MS Wolever, MD | Glycemic Index Laboratories, Inc | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Glycemic Index Laboratories, Inc. | Toronto | Ontario | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21092221 | Derived | Jenkins AL, Kacinik V, Lyon M, Wolever TM. Effect of adding the novel fiber, PGX(R), to commonly consumed foods on glycemic response, glycemic index and GRIP: a simple and effective strategy for reducing post prandial blood glucose levels--a randomized, controlled trial. Nutr J. 2010 Nov 22;9:58. doi: 10.1186/1475-2891-9-58. |
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| ID | Term |
|---|---|
| C540519 | PolyGlycoplex |
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| 7 | Placebo Comparator | Turkey dinner control |
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| 8 | Experimental | Granola |
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| 9 | Experimental | Cornflakes and milk |
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| 10 | Experimental | White Rice |
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| 11 | Experimental | Fruit yogurt |
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| 12 | Experimental | Turkey dinner |
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| 13 | Placebo Comparator | White Bread |
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| 14 | Placebo Comparator | White bread |
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| 15 | Experimental | Granola |
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| PolyGlycopleX (PGX) |
| Dietary Supplement |
5.0 grams of PGX |
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| PolyGlycopleX (PGX) | Dietary Supplement | 0 grams of PGX |
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