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| Name | Class |
|---|---|
| University Hospital, Marseille | OTHER |
| CHU de Reims | OTHER |
| Centre National de la Recherche Scientifique, France | OTHER |
| Institut National de la Santé Et de la Recherche Médicale, France |
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Multicenter prospective study comparing the diagnosis value of high-resolution EEG and depth-EEG to localize the epileptogenic zone in drug resistant partial epilepsies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| high resolution EEG | Experimental |
| |
| Stereo Electroencephalography | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High Resolution EEG | Device | High Resolution EEG |
|
| Measure | Description | Time Frame |
|---|---|---|
| Sensitivity and specificity of electrical source localization of inter-ictal and ictal discharges using high-Resolution EEG for localizing the epileptogenic zone (the stereo-electroencephalography will be the reference method) | results of electrical sources localization of inter-ictal and ictal discharges are compared to the epileptogenic zone defined by SEEG | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| inter-observer reliability of electrical source localization of inter-ictal and ictal discharges for localizing the epileptogenic zone. | sources localization of inter-ictal and ictal discharges will be interpreted by two independant epileptologists, blinded to the results of stereo-EEG. | 3 years |
| sensitivity and specificity of high resolution EEG and electrical source imaging for surgical decision |
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Inclusion Criteria:
Exclusion Criteria:
contraindication to cortectomy
contraindication to depth-EEG
indication of epilepsy surgery without depth-EEG monitoring
high grade glioma, arterio-veinous malformations
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| Name | Affiliation | Role |
|---|---|---|
| Louis Maillard, MD, PhD | Central Hospital, Nancy, France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Marseille | Marseille | 13000 | France | |||
| Central Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19632148 | Background | Maillard L, Koessler L, Colnat-Coulbois S, Vignal JP, Louis-Dorr V, Marie PY, Vespignani H. Combined SEEG and source localisation study of temporal lobe schizencephaly and polymicrogyria. Clin Neurophysiol. 2009 Sep;120(9):1628-36. doi: 10.1016/j.clinph.2009.06.022. Epub 2009 Jul 24. | |
| 20206700 | Background |
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| ID | Term |
|---|---|
| D004828 | Epilepsies, Partial |
| D004194 | Disease |
| ID | Term |
|---|---|
| D004827 | Epilepsy |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| OTHER_GOV |
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| Stereo-electroencephalography | Device | SEEG |
|
|
decision of surgery and the limits of the cortectomy established with electrical source imaging will be compared to the decision of surgery and the limits of the cortectomy established with Stereo-electroencephalography. |
| 3 years |
| Nancy |
| 54000 |
| France |
| Koessler L, Benar C, Maillard L, Badier JM, Vignal JP, Bartolomei F, Chauvel P, Gavaret M. Source localization of ictal epileptic activity investigated by high resolution EEG and validated by SEEG. Neuroimage. 2010 Jun;51(2):642-53. doi: 10.1016/j.neuroimage.2010.02.067. Epub 2010 Mar 4. |
| 21140291 | Result | Koessler L, Cecchin T, Caspary O, Benhadid A, Vespignani H, Maillard L. EEG-MRI co-registration and sensor labeling using a 3D laser scanner. Ann Biomed Eng. 2011 Mar;39(3):983-95. doi: 10.1007/s10439-010-0230-0. Epub 2010 Dec 8. |
| 21095980 | Result | Koessler L, Salido-Ruiz R, Ranta R, Louis-Dorr V, Gavaret M, Maillard L. Influence of source separation and montage on ictal source localization. Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:2898-901. doi: 10.1109/IEMBS.2010.5626321. |
| D010335 |
| Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |