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Epilepsy is a devastating chronic disease due to multiple causes that affect close to 50% of the world's population.
Although effective, epilepsy surgery fails in many cases, the percentage of patients free from crisis on a long term (≥ 5 years) varies from 27% to 66% according to the kind of epilepsy.
It is in this context that EPISTIM is interesting, and its aims isb a better electrophysiology delimiting of cortical networks that imply the genesis of seizures with the aim to improove surgery results.
This study will rely on the intracerebral records and on corticales electrical stimulation as they are currently routinely used by epileptic patients candidates for surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Partial Epilepsy Drug Resistant | Other | Patients with partial Epilepsy Drug Resistant , justifying a SEEG exploration. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Functional stereotaxic exploration | Other | Visual analysis : in order to define the level of cortical resections. Epileptogenic maps : calculated for each crisis and for all crisis in general. Connectivity maps : calculated for each site stimulated at low-frequency. Post-operative evaluation : in order to assess the extent of resection. |
| Measure | Description | Time Frame |
|---|---|---|
| Visual analysis | Visual analysis : in order to define the level of cortical resections. | up to one hour |
| Epileptogenic maps | Epileptogenic maps : calculated for each crisis and for all crisis in general. | up to 10 min |
| Connectivity maps | Connectivity maps : calculated for each site stimulated at low-frequency. | up to 10 min |
| MRI | Post-operative evaluation : in order to assess the extent of resection. MRI : 3D-T1 | up to one hour |
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Inclusion Criteria :
Exclusion Criteria :
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Philippe Kahane, Professor | Contact | 04.76.76.54.48 | philippe.kahane@ujf-grenoble.fr | |
| Lorella Minotti, Hospital Practitioner | Contact | 0476765448 | Lminotti@chu-grenoble.fr |
| Name | Affiliation | Role |
|---|---|---|
| Philippe Kahane, Professor | Grenoble Hospital University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UniversityHospitalGrenoble | Recruiting | La Tronche | 38700 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 7774519 | Background | Alarcon G, Binnie CD, Elwes RD, Polkey CE. Power spectrum and intracranial EEG patterns at seizure onset in partial epilepsy. Electroencephalogr Clin Neurophysiol. 1995 May;94(5):326-37. doi: 10.1016/0013-4694(94)00286-t. | |
| 1370786 | Background | Allen PJ, Fish DR, Smith SJ. Very high-frequency rhythmic activity during SEEG suppression in frontal lobe epilepsy. Electroencephalogr Clin Neurophysiol. 1992 Feb;82(2):155-9. doi: 10.1016/0013-4694(92)90160-j. |
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| ID | Term |
|---|---|
| D004827 | Epilepsy |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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