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| Name | Class |
|---|---|
| Samfundet Folkhälsan | UNKNOWN |
| Sigrid Jusélius Foundation | OTHER |
| Fazer | OTHER |
The purpose of this study is to investigate the antioxidative effects of alkylresorcinols (AR), originating from the rye fiber, on serum LDL particles and the use of AR or it's metabolites as biomarkers for rye fiber intake and the effect of additional plants sterols, incorporated in the rye bread, on serum total and LDL cholesterol concentration.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sterol | Active Comparator | Additional plant sterols incorporated in the rye bread |
|
| control | Placebo Comparator | No added plant sterol in the identical-looking rye bread |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rye-2008 | Dietary Supplement |
|
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Matti J Tikkanen, M.D.. Prof. | Department of Medicine, University of Helsinki, Helsinki, Finland | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Folkhälsan Research Center | Helsinki | Helsinki | 00290 | Finland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22336172 | Derived | Soderholm PP, Alfthan G, Tikkanen MJ, Adlercreutz H. Rye bread intake improves oxidation resistance of LDL in healthy humans. Atherosclerosis. 2012 Apr;221(2):583-6. doi: 10.1016/j.atherosclerosis.2012.01.030. Epub 2012 Jan 25. | |
| 21215605 | Derived | Soderholm PP, Alfthan G, Koskela AH, Adlercreutz H, Tikkanen MJ. The effect of high-fiber rye bread enriched with nonesterified plant sterols on major serum lipids and apolipoproteins in normocholesterolemic individuals. Nutr Metab Cardiovasc Dis. 2012 Jul;22(7):575-82. doi: 10.1016/j.numecd.2010.09.011. Epub 2011 Jan 6. |
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