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| Name | Class |
|---|---|
| University of Eastern Finland | OTHER |
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This study aims to explore whether the increased supply of dietary plant sterols and plant stanols have any influence on serum levels of phytosterols and on consistency of carotid atheromatous plaques.
This is a double-blind randomized study. The study population will consist of 30 consecutive patients who will undergo an elective carotid endarterectomy due to a tight asymptomatic stenosis. The patients will be randomized into two groups consuming either plant sterol (2g/day) or plant stanol (2g/day) spreads for two to six weeks, until the operation. Serum lipids, lipoproteins and sterols will be analyzed at the randomization, before the operation and one month after the operation. The carotid arteries will be examined for their composition of sterols.
This study gives new information concerning the relationship between dietary consumption of plant sterols and stanols and the sterol composition of the carotid plaques.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | A group of subjects consuming daily 2 grams of plant stanols 4-6 weeks before the operation |
|
| 2 | Active Comparator | A group of patients consuming daily 2 grams of plant sterols 4-6 weeks before the operation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Plant Stanol | Dietary Supplement | Plant stanols in margarines daily 2 grams |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Sterols in serum and carotid plaques at the operation | at operation and one month after operation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Tatu A. Miettinen, professor | Dept. of Medicine, Div. of Internal Medicine, Helsinki Univ. Central Hospital, Biomedicum Helsinki | Principal Investigator |
| Helena Gylling, Professor | Department of Clinical Nutrition, University of Kuopio and Kuopion University Central Hospital, Kuopio, Finland | Principal Investigator |
| Markku J Nissinen, MD, PhD | Dept. of Medicine, Div. of Gastroenterology, HUCH, Helsinki, Finland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Surgery, Div. of Vascular Surgery, Helsinki University Central Hospital | Helsinki | 00029 | Finland |
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| ID | Term |
|---|---|
| D050197 | Atherosclerosis |
| ID | Term |
|---|---|
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D012855 | Sitosterols |
| D010840 | Phytosterols |
| ID | Term |
|---|---|
| D002782 | Cholestenes |
| D002776 | Cholestanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
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| Plant Sterol |
| Dietary Supplement |
Plant sterols in margarines daily 2 grams |
|
| D011083 |
| Polycyclic Compounds |
| D013261 | Sterols |
| D008563 | Membrane Lipids |
| D008055 | Lipids |
| D064209 | Phytochemicals |
| D001685 | Biological Factors |