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| ID | Type | Description | Link |
|---|---|---|---|
| F31AT005384-01 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Center for Complementary and Integrative Health (NCCIH) | NIH |
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The purpose of this study is to determine whether older adults (ages 65-89) who consume the dietary supplement Juven (Abbott Laboratories) versus placebo for 6 months will demonstrate increases in fat-free mass, muscle volume,and physical function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Juven | Experimental | Participants in the treatment arm will receive the dietary supplement Juven. |
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| Placebo | Placebo Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Juven | Dietary Supplement | Participants in the treatment arm will be asked to consume 2 packets of Juven drink mix each day for a period of six months. |
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| Measure | Description | Time Frame |
|---|---|---|
| Fat-free mass as determined by a four-compartment model of body composition | Baseline, 3-months, 6-months |
| Measure | Description | Time Frame |
|---|---|---|
| Appendicular lean mass as determined by dual energy X-ray absorptiometry | Baseline, 3-months, 6-months | |
| Muscle volume as determined by magnetic resonance imaging | Baseline and 6-months | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Amy C Ellis, MPH | University of Alabama at Birmingham | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29672184 | Derived | Ellis AC, Hunter GR, Goss AM, Gower BA. Oral Supplementation with Beta-Hydroxy-Beta-Methylbutyrate, Arginine, and Glutamine Improves Lean Body Mass in Healthy Older Adults. J Diet Suppl. 2019;16(3):281-293. doi: 10.1080/19390211.2018.1454568. Epub 2018 Apr 19. |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| Juven | Dietary Supplement | Participants in the placebo arm will be asked to consume two packets of an orange-flavored drink mix each day for a period of six months. |
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| Physical function as determined by questionnaire and a battery of physical performance tests |
| Baseline and 6 months |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |