Sympathetic Neural Outflow During Xenon Anesthesia in Humans

Sympathetic Neural Outflow During Xenon Anesthesia in Humans

The purpose of this study is to test the hypothesis that sympathetic neural outflow to muscles as well as a sympathetic baroreflexes are not altered during xenon anesthesia in Healthy Volunteers.

Objectives for this study :

• Main Objective : Influence of Xenon anesthesia on Sympathetic Nervous Activity
• Secondary Objectives : Security under LENOXe™ (xénon 100 % v/v) anesthesia

Inclusion Criteria:

• Healthy volunteers > 18 years and < 65 years of age
• ASA physical status I
• Legal competence
• for whom the consent form has been signed

Exclusion Criteria:

• Healthy volunteers < 18 years and > 65 years of age
• Pregnancy, lactation period or missing secure anticonvulsive therapy
• Missing legal competence
• Participation in other clinical trials
• Contraindications as mentioned on §4.3 of the SPCs of LENOXe™ (xénon 100 % v/v)
• Any medication especially of Sildenafil (Viagra®) or other potency remedy
• Existing relationship of dependency to the sponsor or the investigator