Hemodynamic Stability During Carotid Endarterectomy.Comparison of LENOXe™ (Xenon 100% v/v) Versus Sevoflurane

Hemodynamic Stability During Carotid Endarterectomy Under General Anesthesia in Elderly Patients: Comparison LENOXe™ (xénon 100% v/v) Versus SEVOFLURANE

The purpose of this study is to compare the hemodynamics effects of two usual hypnotic agents (LENOXe ™ (xenon 100 % v/v) and sevoflurane) during a general anesthesia for carotid endarterectomy in elderly patients. The hypothesis is that the use of the LENOXe ™ (xenon 100 % v/v) allows to obtain per-operating hemodynamic stability non inferior than with sevoflurane.

Inclusion Criteria:

• Patients > 55 years, status ASA II
• Carotid endarterectomy elected surgery
• Signed informed consent

Exclusion Criteria:

Related to the patients:

• Histories of hypersensibility in both products used in the study
• uncontrolled arterial High Blood Pressure in the preoperative anaesthesia screening
• Severe cardiac failure (FEVG < 30 %)
• Major lung or airways disease and\or required per-operating FiO2> 35 %
• Elevated intracranial pressure
• Pregnancy, breast feeding
• Major protected, under supervision, under guardianship
• Every patient entering within the framework of the contraindications indicated to §4.3 of the summary of the characteristics of tested products (LENOXe ™ (xenon 100 % v/v), sevoflurane)

Related to the surgery:

• Controlateral carotid stenosis superior to 70 % and\or preoperative indication in the implementation per-operating of a carotid shunt
• Surgery realized within the framework of an emergency
• Combined Surgery