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| ID | Type | Description | Link |
|---|---|---|---|
| 2012-001827-11 |
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The effects on brain perfusion of the two currently vasopressors used to treat accidental hypotension occurring during carotid surgery (i.e. ephedrine and phenylephrine) is not known, but a disadvantage to use phenylephrine is suspected, due to its mechanism of action and according to published reports
This is a randomised trial comparing ephedrine and phenylephrine as used for accidental hypotension occurring during carotid surgery, on cerebral perfusion, assessed by near-infrared spectroscopy (NIRS).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ephedrine | Experimental | This is a randomised trial comparing ephedrine and phenylephrine as used for accidental hypotension occurring during carotid surgery, on cerebral perfusion, assessed by near-infrared spectroscopy (NIRS). |
|
| phenylephrine | Experimental | This is a randomised trial comparing ephedrine and phenylephrine as used for accidental hypotension occurring during carotid surgery, on cerebral perfusion, assessed by near-infrared spectroscopy (NIRS). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ephedrine and phenylephrine | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cerebral oxygen saturation (SctO2) | at day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of post-treatment hypotension | At day 1 | |
| Incidence of post-treatment bradycardia | at day 1 | |
| Postoperative morbidity: cardiovascular, cerebral, renal, surgical |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Charlotte BAUD | University Hospital, Clermont-Ferrand | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Clermont-Ferrand | Clermont-Ferrand | 63003 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28378467 | Background | Aliane J, Duale C, Guesmi N, Baud C, Rosset E, Pereira B, Bouvier D, Schoeffler P. Compared effects on cerebral oxygenation of ephedrine vs phenylephrine to treat hypotension during carotid endarterectomy. Clin Exp Pharmacol Physiol. 2017 Jul;44(7):739-748. doi: 10.1111/1440-1681.12759. |
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| ID | Term |
|---|---|
| D007022 | Hypotension |
| D002545 | Brain Ischemia |
| D020521 | Stroke |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
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| ID | Term |
|---|---|
| D004809 | Ephedrine |
| D010656 | Phenylephrine |
| ID | Term |
|---|---|
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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| at day 1 |
| Postoperative recovery | at day 1 |
| D002493 |
| Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020005 |
| Propanols |
| D000588 | Amines |
| D010627 | Phenethylamines |
| D005021 | Ethylamines |
| D004983 | Ethanolamines |