A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia

Effects of Vasopressor on Cerebral Oxygenation During General Anesthesia in Abdominal Surgery

The purpose of this study is to investigate whether norepinephrine(N), phenylephrine(P) or ephedrine(E) have different effect on cerebral oxygenation in abdominal surgery with propofol or sevoflurane.

This study was a single-center, randomized, double-blinded, controlled trial. First, the effects of E, P, or N on cerebral oxygen saturation(rScO2) under general anesthesia in abdominal surgery were studied. Patients with abdominal surgery were evaluated using near-infrared spectroscopy. Continual changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO) and systemic vascular resistance (SVR) will be measured with LiDCO rapidV3 monitoring system. To investigate the individualized therapeutic options & specific mechanisms of the three vasopressors on rScO2 and CO.

Inclusion Criteria:

• ASA I-III, age 18-80 years
• Elective abdominal surgery
• Signed informed consent

Exclusion Criteria:

• ASA≥IV
• Preoperative unstable blood hemodynamics
• Allergy to ephedrine, phenylephrine or norepinephrine
• Decrease in MAP <20%
• Severe cardiovascular disorder