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The purpose of this study is to investigate whether norepinephrine(N), phenylephrine(P) or ephedrine(E) have different effect on cerebral oxygenation in abdominal surgery with propofol or sevoflurane.
This study was a single-center, randomized, double-blinded, controlled trial. First, the effects of E, P, or N on cerebral oxygen saturation(rScO2) under general anesthesia in abdominal surgery were studied. Patients with abdominal surgery were evaluated using near-infrared spectroscopy. Continual changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO) and systemic vascular resistance (SVR) will be measured with LiDCO rapidV3 monitoring system. To investigate the individualized therapeutic options & specific mechanisms of the three vasopressors on rScO2 and CO.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ephedrine-Propofol | Experimental | receive ephedrine 0.15mg/kg (configured concentration 6mg/mL) when MAP was a 20% decrease in baseline blood pressure after both induction of anesthesia and tracheal intubation. |
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| Phenylephrine-propofol | Experimental | receive phenylephrine 2.5ug/kg(configured concentration 100ug/mL) when MAP was a 20% decrease in baseline blood pressure after both induction of anesthesia and tracheal intubation. |
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| Norepinephrine-propofol | Experimental | receive norepinephrine 0.2ug/kg(configured concentration 8μg/ml) when MAP was a 20% decrease in baseline blood pressure after both induction of anesthesia and tracheal intubation. |
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| Ephedrine-sevoflurane | Active Comparator | receive Ephedrine 0.15mg/kg(configured concentration 6mg/mL) when MAP was a 20% decrease in baseline blood pressure after both induction of anesthesia and tracheal intubation. |
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| Phenylephrine-sevoflurane | Active Comparator | receive phenylephrine 2.5ug/kg(configured concentration 80ug/mL) when MAP was a 20% decrease in baseline blood pressure after both induction of anesthesia and tracheal intubation. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ephedrine-P | Drug | after induction of anesthesia, use total intravenous anesthesia maintained with propofol |
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| Measure | Description | Time Frame |
|---|---|---|
| Continual changes in Cerebral Oxygen Saturation | This outcome is measured by near-infrared spectroscopy | 10 minutes after entering the operating room; when 20% decrease in baseline MAP after both induction of anesthesia and intubation; when MAP rising to the highest point after administration of vasopressors |
| Measure | Description | Time Frame |
|---|---|---|
| Continual changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP) | This outcome is measured by LiDCO rapidV3 monitoring system | 10 minutes after entering the operating room; when 20% decrease in baseline MAP after both induction of anesthesia and intubation; when MAP rising to the highest point after administration of vasopressors |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Liping Han, MD, MSc | Contact | 86-411-84412001 | han651310@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Hong Fang, MD | Dalian Municipal Central Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dalian Municipal Central Hospital | Recruiting | Dalian | Liaoning | 116033 | China |
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| ID | Term |
|---|---|
| D007022 | Hypotension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D014662 | Vasoconstrictor Agents |
| C014526 | ephedrine phosphate |
| ID | Term |
|---|---|
| D002317 | Cardiovascular Agents |
| D045506 | Therapeutic Uses |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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| Norepinephrine-sevoflurane | Active Comparator | receive norepinephrine 0.2ug/kg(configured concentration 8ug/mL) when MAP was a 20% decrease in baseline blood pressure after both induction of anesthesia and tracheal intubation. |
|
| Phenylephrine-P | Drug | after induction of anesthesia, use total intravenous anesthesia maintained with propofol |
|
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| Norepinephrine-P | Drug | after induction of anesthesia, use total intravenous anesthesia maintained with propofol |
|
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| Ephedrine-S | Drug | after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane |
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| Phenylephrine-S | Drug | after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane |
|
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| Norepinephrine-S | Drug | after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane |
|
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| Continual changes in heart rate (HR) | This outcome is measured by LiDCO rapidV3 monitoring system | 10 minutes after entering the operating room; when 20% decrease in baseline MAP after both induction of anesthesia and intubation; when MAP rising to the highest point after administration of vasopressors |
| Continual changes in stroke volume (SV) | This outcome is measured by LiDCO rapidV3 monitoring system | 10 minutes after entering the operating room; when 20% decrease in baseline MAP after both induction of anesthesia and intubation; when MAP rising to the highest point after administration of vasopressors |
| Continual changes in cardiac output (CO) | This outcome is measured by LiDCO rapidV3 monitoring system | 10 minutes after entering the operating room; when 20% decrease in baseline MAP after both induction of anesthesia and intubation; when MAP rising to the highest point after administration of vasopressors |
| Continual changes in systemic vascular resistance (SVR) | This outcome is measured by LiDCO rapidV3 monitoring system | 10 minutes after entering the operating room; when 20% decrease in baseline MAP after both induction of anesthesia and intubation; when MAP rising to the highest point after administration of vasopressors |