Xenon as an Adjuvant to Propofol Anaesthesia in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery.

Xenon as an Adjuvant to Propofol Anaesthesia in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery:a Randomised Controlled Trial

The investigators hypothesize that the application of 30% xenon as an adjuvant to general anesthesia with a target-controlled infusion of propofol is superior to general anesthesia with propofol alone with respect to hemodynamic stability.

Inclusion Criteria:

• patients with coronary artery disease scheduled for elective OPCAB-surgery
• patients willing and able to complete the requirements of this study
• Ejection fraction >30%

Exclusion Criteria:

• Lack of informed consent
• age < 18 years
• COPD GOLD >II
• Renal dysfunction defined as serum-creatinine >1.5mg/dl
• acute coronary syndrome during the last 24 hours; haemodynamic instability, requirement of inotropic support
• single vessel grafting
• disabling neuropsychiatric disorders (severe dementia, Alzheimer's disease, schizophrenia, depression, low preoperative cognitive state (MMSE at baseline <25), history of stroke with residuals, increased intracranial pressure
• Hypersensitivity to the study medication
• Presumed uncooperativeness or legal incapacity