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| Name | Class |
|---|---|
| Vejle Hospital | OTHER |
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The purpose of this study is to investigate the relation between vitamin D production after UVB and exposed body surface areas with different UVB doses.
Vitamin D deficiency is very common. Rachitis, osteoporosis, cancer, sclerosis as well as cardiovascular diseases are related to vitamin D deficiency. Elderly people, immigrants as well as patients with malabsorption diseases often have vitamin D deficiency. 90-95 % of the total vitamin D requirements are obtained from the ultraviolet (UV) radiation of the skin.In spite of the risk of skin-cancer, treatment with sunlight radiation is often recommended against vitamin D deficiency. This fact has raised a scientific debate, where concern has been expressed with regard to the risk of skin-cancer. This dilemma should also be examined as no human studies are available on the vitamin D production in the skin after UV-radiation showing the frequency and dose necessary for sufficient production of vitamin D. The lowest exposure frequency, the smallest body surface area and the lowest UV dose should therefore be established to be exposed in order to minimize the risk of skin-cancer by unnecessary UV-radiation. The purpose of the project is therefore to clarify which factors there are of importance for the production of vitamin D in the skin after UVB radiation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 2 | Active Comparator | Body surface area: 12 % |
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| 1 | Active Comparator | Body surface area: 6 % |
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| 3 | Active Comparator | Body surface area: 24 % |
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| 4 | Active Comparator | Body surface area: 6 % |
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| 5 | Active Comparator | Body surface area: 12 % |
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| 6 | Active Comparator | Body surface area: 24 % |
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| 7 |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Broadband UVB | Radiation | UVB dose: 0.75 SED. Four UVB sessions with 2 days in between. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Vitamin D (nmol/l) measured in a blood sample to define just how much sun exposure is necessary to obtain a sufficient vitamin D production. | Before and 2 days after the last UVB session. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hans Christian Wulf, Full Prof. | Bispebjerg Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bispebjerg Hospital, Department of Dermatology D92, Bispebjerg Bakke 23, | Copenhagen Nv | Copenhagen | 2400 | Denmark |
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Body surface area: 6 % |
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| 8 | Active Comparator | Body surface area: 12 % |
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| 9 | Active Comparator | Body surface area: 24 % |
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| Broadband UVB |
| Radiation |
UVB dose: 0.75 SED. Four UVB sessions with 2 days in between. |
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| Broadband UVB | Radiation | UVB dose: 0.75 SED. Four UVB sessions with 2 days in between. |
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| Broadband UVB | Radiation | UVB dose: 1.5 SED. Four UVB sessions with 2 days in between. |
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| Broadband UVB | Radiation | UVB dose: 1.5 SED. Four UVB sessions with 2 days in between. |
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| Broadband UVB | Radiation | UVB dose: 1.5 SED. Four UVB sessions with 2 days in between. |
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| Broadband UVB | Radiation | UVB dose: 3.0 SED. Four UVB sessions with 2 days in between. |
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| Broadband UVB | Radiation | UVB dose: 3.0 SED. Four UVB sessions with 2 days in between. |
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| Broadband UVB | Radiation | UVB dose: 3.0 SED. Four UVB sessions with 2 days in between. |
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