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The investigators aim to investigate the relationship between albuminuria and arterial stiffness in diabetic patients, hypertensive patients and healthy subjects.
CONTEXT: Albuminuria is an important cardiovascular risk factor. Arterial stiffness also gives important information about atherosclerosis. Oscillometric methods may be useful in assessing arterial stiffness in a mainly operator independent way.
OBJECTIVE: We aim to investigate the relationship between albuminuria and arterial stiffness measured with an oscillometric device in diabetic patients, hypertensive patients and healthy subjects.
METHODS: 152 diabetic patients, 152 hypertensive patients and 152 healthy subjects are planned to be enrolled in this study. The measurements will be done between 9:00 and 13:00. After the measurements, blood and urine samples will be obtained, centrifugated and kept in -80°C until assayed. Afterwards, echocardiographic left ventricle mass index will be calculated. The correlation between albuminuria and arterial stiffness will be assessed as the primary outcome measure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diabetic patients | Hypertensive and normotensive patients with type 2 diabetes mellitus | ||
| Hypertensive patients | Patients with essential hypertension | ||
| Healthy subjects | Healthy subjects |
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| Measure | Description | Time Frame |
|---|---|---|
| Correlation between albuminuria and arterial stiffness | Albuminuria and arterial stiffness will be assessed simultaneously (i.e. in the same morning) |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with diabetes, patients with hypertension and healthy subjects
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| Name | Affiliation | Role |
|---|---|---|
| Omer Kaya, MD | Istanbul Univesity Istanbul Medical Faculty Department of Internal Medicine | Study Chair |
| Abdullah Ozkok, MD | Istanbul Univesity Istanbul Medical Faculty Department of Internal Medicine | Study Chair |
| Bahtiyar Toz, MD | Istanbul Univesity Istanbul Medical Faculty Department of Internal Medicine | Study Chair |
| Kadri Atay, MD | Istanbul Univesity Istanbul Medical Faculty Department of Internal Medicine | Study Chair |
| Hamza Ugur Bozbey, MD | Istanbul Univesity Istanbul Medical Faculty Department of Internal Medicine | Study Chair |
| Ercan Bicakci, MD | Istanbul Univesity Istanbul Medical Faculty Department of Internal Medicine | Study Chair |
| Mehmet Besiroglu, MD | Istanbul Univesity Istanbul Medical Faculty Department of Internal Medicine | Study Chair |
| Fatih Tufan, MD | Istanbul Univesity Istanbul Medical Faculty Department of Internal Medicine Division of Geriatrics | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Istanbul Univesity Istanbul Medical Faculty Department of Internal Medicine | Istanbul | 34390 | Turkey (Türkiye) |
yes
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D006973 | Hypertension |
| D000419 | Albuminuria |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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Serum and urine samples.
| Tevfik Ecder, Prof |
| Istanbul Univesity Istanbul Medical Faculty Department of Internal Medicine Division of Nephrology |
| Principal Investigator |
| Miklos Illyes, MD, Ph. D | Heart Institute, Pecs University Faculty of Medicine, Pecs/Hungary | Study Director |
| Kamil Nas, MD | Szent Janos Hospital Radiology Department, Budapest/Hungary | Study Director |
| Molnar Ferenc | Tensiomed Arterial Stiffness Centre, Budapest/Hungary | Study Director |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D011507 | Proteinuria |
| D014555 | Urination Disorders |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D020924 | Urological Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |