Identifying Changes in Blood (Potential Biomarkers) in Individuals With Drug-Induced Liver Injury

Identification of New Biomarkers of Drug Induced Liver Injury

The purpose of this study is to try to develop new blood tests that may help doctors identify if a drug is hurting a person's liver.

Our hypothesis is that there are liver-specific particles, called mRNA, that are identifiable in a person's blood sample during liver injury caused by some drugs. The purpose of this study is to try to develop new blood tests that may help doctors identify if a drug is hurting a person's liver, perhaps early in the process before significant injury or illness have occurred.

Inclusion Criteria:

• ALT > 200 IU/L at presentation to UNC Hospitals
• Drug induced liver injury considered likely by admitting medical staff