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no enrollment
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| Name | Class |
|---|---|
| University of Washington | OTHER |
| Denver Health Medical Center | OTHER |
| Children's Hospital Medical Center, Cincinnati | OTHER |
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The purpose of this study is to find new blood and urine tests that detect acute kidney injury earlier than our current blood tests in patients receiving a liver transplant.
Patients with end stage liver disease that receive a liver transplant will be studied to determine if novel serum and urine biomarkers (serum cystatin C, urine interleukin-18 [IL-18] and urine neutrophil gelatinase associated lipocalin [NGAL]) can predict the outcome measures listed above.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Liver transplant recipients |
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| Measure | Description | Time Frame |
|---|---|---|
| Development of acute kidney injury as defined by a 50% increase in serum creatinine | Within 2 to 5 days of liver transplant that is sustained for at least 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Development of severe acute kidney injury, as defined as a doubling of serum creatinine | Within 2-5 days of transplant that is sustained for at least 24 hours | |
| The need for renal replacement therapy | After liver transplant operation to discharge |
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Inclusion Criteria:
Exclusion Criteria:
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All patients presenting to the University of Colorado Hospital or the University of Washington Medical Center for a liver transplant operation
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| Name | Affiliation | Role |
|---|---|---|
| Angela M Walcher, MD | University of Colorado, Denver | Principal Investigator |
| Charles L Edelstein, MD, PhD | University of Colorado, Denver | Study Director |
| Connie L Davis, MD | University of Washington | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Colorado Denver | Aurora | Colorado | 80045 | United States | ||
| University of Washington |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18565474 | Background | Edelstein CL. Biomarkers of acute kidney injury. Adv Chronic Kidney Dis. 2008 Jul;15(3):222-34. doi: 10.1053/j.ackd.2008.04.003. | |
| 16710348 | Background | Parikh CR, Mishra J, Thiessen-Philbrook H, Dursun B, Ma Q, Kelly C, Dent C, Devarajan P, Edelstein CL. Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery. Kidney Int. 2006 Jul;70(1):199-203. doi: 10.1038/sj.ki.5001527. Epub 2006 May 17. |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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Urine supernatent Serum
| All cause mortality | After liver transplant operation to discharge |
| Seattle |
| Washington |
| 98105 |
| United States |
| 16148039 | Background | Parikh CR, Abraham E, Ancukiewicz M, Edelstein CL. Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit. J Am Soc Nephrol. 2005 Oct;16(10):3046-52. doi: 10.1681/ASN.2005030236. Epub 2005 Sep 7. |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |