S9007, Cytogenetic Studies in Leukemia Patients
S9007, Cytogenetic Studies in Leukemia Patients
RATIONALE: Studying samples of bone marrow and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.
PURPOSE: This research study is looking at bone marrow and blood samples from patients with leukemia or other hematopoietic cancers.
Primary objective:
* Maintain and expand a database of cytogenetic information on leukemia patients.
Other objectives as funding permits:
OUTLINE: Bone marrow and/or peripheral blood samples from patients on specific treatment protocols for leukemia are analyzed for cytogenetic abnormalities. Samples from patients with chronic lymphocytic leukemia (CLL) are analyzed for trisomy 12 by fluorescence in situ hybridization and conventional cytogenetics.
PROJECTED ACCRUAL: Approximately 2,500 patients (1,200 with first-line acute myeloid leukemia [AML], 500 with first-line acute lymphoblastic leukemia [ALL], 200 with relapsed AML, 125 with chronic phase chronic myelogenous leukemia [CML], 100 with accelerated phase or blastic phase CML, 250 with hairy cell leukemia, and 125 with relapsed ALL or CLL) will be accrued for this study within 5 years.
DISEASE CHARACTERISTICS:
Registered on one of the following Southwest Oncology Group treatment protocols:
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
Tucson, Arizona 85724-5024, United States
Fort Smith, Arkansas 72903, United States
Burbank, California 91505, United States
Marysville, California 95901, United States
Hartford, Connecticut 06105, United States
Boise, Idaho 83706, United States
Boise, Idaho 83712, United States
Maywood, Illinois 60153, United States
Normal, Illinois 61761, United States
Beech Grove, Indiana 46107, United States
Des Moines, Iowa 50309, United States
Des Moines, Iowa 50314, United States
Kansas City, Kansas 66160-7357, United States
Wichita, Kansas 67214, United States
Lexington, Kentucky 40536-0093, United States
Shreveport, Louisiana 71130-3932, United States
Dearborn, Michigan 48123-2500, United States
Grosse Pointe Woods, Michigan 48236, United States
Kessler Air Force Base, Mississippi 39534, United States
Billings, Montana 59102, United States
Missoula, Montana 59807, United States
Charlotte, North Carolina 28232-2861, United States
Charlotte, North Carolina 28233-3549, United States
Portland, Oregon 97213-2967, United States
Portland, Oregon 97239-3098, United States
Charleston, South Carolina 29425, United States
Spartanburg, South Carolina 29303, United States
Sioux Falls, South Dakota 57117-5039, United States
Houston, Texas 77030, United States
San Antonio, Texas 78229-3900, United States
Seattle, Washington 98122-4307, United States
Seattle, Washington 98195, United States
Green Bay, Wisconsin 54301-3526, United States