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| ID | Type | Description | Link |
|---|---|---|---|
| CCG-B945 | Other Identifier | Children's Cancer Group | |
| CDR0000538662 | Other Identifier | Clinical Trials.gov | |
| COG-B945 | Other Identifier | Children's Oncology Group |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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RATIONALE: Studying samples of bone marrow and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This laboratory study is looking at DNA in bone marrow and blood samples from young patients with acute myeloid leukemia or acute lymphoblastic leukemia.
OBJECTIVES:
OUTLINE: This is a multicenter study.
Bone marrow or blood are collected and analyzed by Southern blot for chromosome 11q23 breakpoints and translocations. Samples from patients with secondary acute myeloid leukemia are also examined for MLL gene rearrangements.
PROJECTED ACCRUAL: A total of 250 patients will be accrued for this study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| All Patients | Completion of Telephone Study Entry Form, Additional On Study Form, and Specimen Transmittal Form. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Southern blotting | Genetic |
| ||
| chromosomal translocation analysis |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical, morphologic, immunologic, cytogenetic, and molecular characteristics of acute lymphoblastic leukemia and de novo and secondary acute myeloid leukemia (AML) | ||
| Comparison of secondary AML vs de novo AML at the level of Southern blot, breakpoint sequence, and DNA topoisomerase II cleavage sites |
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DISEASE CHARACTERISTICS:
Diagnosis of leukemia meeting 1 of the following criteria:
Bone marrow sample, peripheral blood (WBC > 10,000/mm³ and 20% peripheral blasts), or pheresis bag available
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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| Name | Affiliation | Role |
|---|---|---|
| Beverly J. Lange, MD | Children's Hospital of Philadelphia | Study Chair |
| Carolyn A. Felix, MD | Children's Hospital of Philadelphia |
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marrow, blood, pheresis bag
| Genetic |
|
| cytogenetic analysis | Genetic |
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| gene rearrangement analysis | Genetic |
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| mutation analysis | Genetic |
|
| ID | Term |
|---|---|
| D007938 | Leukemia |
| D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
| ID | Term |
|---|---|
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007945 | Leukemia, Lymphoid |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| D015139 | Blotting, Southern |
| D020732 | Cytogenetic Analysis |
| D015321 | Gene Rearrangement |
| ID | Term |
|---|---|
| D004586 | Electrophoresis |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
| D055664 | Electrochemical Techniques |
| D015336 | Molecular Probe Techniques |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D005821 | Genetic Techniques |
| D055614 | Genetic Phenomena |
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