Molecular and Cytogenetic Monitoring of CML - A Mandatory Companion to CALGB 19804
Molecular and Cytogenetic Monitoring of CML - A Mandatory Companion to CALGB 19804
RATIONALE: Studying samples of blood and bone marrow from patients with cancer may help doctors identify biomarkers related to cancer.
PURPOSE: This research study is looking at blood and bone marrow samples in patients with chronic myelogenous leukemia enrolled on a CALGB clinical trial.
OBJECTIVES:
OUTLINE: Peripheral blood samples and bone marrow aspirates are collected at baseline and at 3, 6, and 9 months after starting therapy. If patient continues to receive protocol treatment after 9 months, additional peripheral blood samples are collected every 6 months and bone marrow aspirates are taken annually. In the event of disease progression (blast crisis), an additional peripheral blood sample and bone marrow aspirate are collected.
Samples are examined by quantitative Southern blot analysis with probes to BCR, quantitative reverse transcriptase-polymerase chain reaction analysis for BCR/ABL fusion transcripts, and cytogenetic analysis.
PROJECTED ACCRUAL: A total of 60 patients will be accrued for this study within 1.5 years.
Inclusion Criteria:
Clinical diagnosis of chronic myelogenous leukemia (CML)
Concurrent enrollment on a CALGB treatment protocol for newly diagnosed or previously treated CML (e.g, CLB-19804)
Washington D.C., District of Columbia 20057, United States
Hollywood, Florida 33021, United States
Baltimore, Maryland 21201, United States
Worcester, Massachusetts 01605, United States
Columbia, Missouri 65203, United States
St Louis, Missouri 63141, United States
Voorhees Township, New Jersey 08043, United States
East Syracuse, New York 13057, United States
Syracuse, New York 13057, United States
Winston-Salem, North Carolina 27157-1096, United States
Columbus, Ohio 43210, United States
Pittsburgh, Pennsylvania 15224-1791, United States
Spartanburg, South Carolina 29307, United States
Berlin Corners, Vermont 05602, United States
Burlington, Vermont 05401, United States
White River Junction, Vermont 05009, United States