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| ID | Type | Description | Link |
|---|---|---|---|
| U01CA121947 | U.S. NIH Grant/Contract | View source | |
| CDR0000648183 | Other Identifier | NCI |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
| The Emmes Company, LLC | INDUSTRY |
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RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is looking at blood and tissue samples from patients with aggressive non-Hodgkin B-cell lymphoma or Hodgkin lymphoma.
OBJECTIVES:
Primary
Secondary
OUTLINE: This is a multicenter study.
Blood and tissue samples collected at the time of diagnosis are analyzed for serum free light chain and clonal immunoglobulin (Ig) DNA rearrangements and circulating clonotypic B-cells via PCR.
PROJECTED ACCRUAL: A total of 50 patients (25 with diffuse large B-cell/immunoblastic histologies, 15 with Burkitt lymphoma, and 10 with Hodgkin lymphoma) will be accrued for this study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Specimen Collection | Subjects with a diagnosis of HIV and an untreated aggressive B-cell lymphoma. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| polymerase chain reaction | Genetic | determination of elevated serum FLC and clonal Ig detection rates in plasma and tumor |
|
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of patients with diffuse large B-cell/immunoblastic and Burkitt histologies with elevated serum free light chains (FLC) | Study entry | |
| Proportion of patients with Hodgkin lymphoma clonal immunoglobulin (Ig) DNA detection in the plasma | Study entry |
| Measure | Description | Time Frame |
|---|---|---|
| Agreement between the detection of a monoclonal Ig DNA spike in plasma and the detection of a monoclonal DNA spike in tumor tissue | Study entry | |
| Agreement between the fragment length of a spike in tumor tissue and the fragment length of the spike in plasma |
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DISEASE CHARACTERISTICS:
Diagnosis of an untreated aggressive B-cell lymphoma, including:
Serological documentation of HIV infection by any of the FDA-approved tests
Available diagnostic material from fresh frozen tissue or formalin-fixed paraffin embedded tissue OR willing to undergo a repeat biopsy (fine needle aspiration is acceptable)
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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Persons with HIV infection and a diagnosis of an untreated aggressive B-cell lymphoma.
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| Name | Affiliation | Role |
|---|---|---|
| Nina Wagner-Johnston, MD | Mallinckrodt Institute of Radiology at Washington University Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rebecca and John Moores UCSD Cancer Center | La Jolla | California | 92093-0658 | United States | ||
| UCLA Clinical AIDS Research and Education (CARE) Center |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28508728 | Derived | Wagner-Johnston ND, Lensing S, Noy A, Ratner L, Henry D, Lee JY, Silver S, Faham M, Ambinder RF. High frequency of identical clonal immunoglobulin DNA in pre-treatment tumor and plasma from untreated patients with HIV-associated lymphoma: prospective multicenter trial of the AIDS malignancies consortium (AMC 064). Leuk Lymphoma. 2017 Dec;58(12):2939-2942. doi: 10.1080/10428194.2017.1317095. Epub 2017 May 16. |
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5 tubes of peripheral blood collected along with available tissue blocks or fresh frozen tissue collected at baseline.
| laboratory biomarker analysis | Other | determination of elevated serum FLC and clonal Ig detection rates in plasma and tumor |
|
| Study entry |
| Detection rate of elevated FLC in each histology, including diffuse large B-cell/immunoblastic and Burkitt lymphoma | Study entry |
| Detection rate of clonal Ig DNA in each histology, including diffuse large B-cell/immunoblastic, Burkitt lymphoma, and Hodgkin lymphoma | Study entry |
| Analysis of the clinical and pathologic correlates of detection by the serum/plasma tests: disease subtype, stage of disease, disease bulk, lactate dehydrogenase, and Ki67 index | Study entry |
| Detection rate of clonotypic B cells in peripheral blood mononuclear cells from patients with Hodgkin lymphoma | Study entry |
| Los Angeles |
| California |
| 90024 |
| United States |
| University of California at Davis Center for Aids Research and Education Services | Sacramento | California | 95814 | United States |
| UCSF Helen Diller Family Comprehensive Cancer Center | San Francisco | California | 94115 | United States |
| University of Miami | Miami | Florida | 33136 | United States |
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | 21231-2410 | United States |
| Boston University Cancer Research Center | Boston | Massachusetts | 02118 | United States |
| Mallinckrodt Institute of Radiology at Washington University Medical Center | St Louis | Missouri | 63110 | United States |
| Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis | St Louis | Missouri | 63110 | United States |
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10021 | United States |
| Montefiore Medical Center | The Bronx | New York | 10467-2490 | United States |
| UNC Hospitals, The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599 | United States |
| Pennsylvania Oncology Hematology Associates, Incorporated - Philadelphia | Philadelphia | Pennsylvania | 19106 | United States |
| Thomas Street Health Center | Houston | Texas | 77009 | United States |
| Baylor University Medical Center - Houston | Houston | Texas | 77030-2707 | United States |
| Benaroya Research Institute at Virginia Mason Medical Center | Seattle | Washington | 98101 | United States |
| ID | Term |
|---|---|
| D008223 | Lymphoma |
| D015658 | HIV Infections |
| D006689 | Hodgkin Disease |
| D002051 | Burkitt Lymphoma |
| D016403 | Lymphoma, Large B-Cell, Diffuse |
| D016400 | Lymphoma, Large-Cell, Immunoblastic |
| ID | Term |
|---|---|
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D015229 | Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D020031 | Epstein-Barr Virus Infections |
| D006566 | Herpesviridae Infections |
| D004266 | DNA Virus Infections |
| D014412 | Tumor Virus Infections |
| D016393 | Lymphoma, B-Cell |
| D008228 | Lymphoma, Non-Hodgkin |
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| ID | Term |
|---|---|
| D016133 | Polymerase Chain Reaction |
| ID | Term |
|---|---|
| D021141 | Nucleic Acid Amplification Techniques |
| D005821 | Genetic Techniques |
| D008919 | Investigative Techniques |
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