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Evaluate the efficacy of ketorolac 0.5%, a topical non-steroidal anti-inflammatory drug (NSAID), to prevent macular edema after epiretinal membrane surgery. Patients undergoing epiretinal membrane surgery have increased risk of macular swelling which can adversely affect vision. Since post-intraocular surgery inflammation is a contributing factor to macular swelling and loss of vision, NSAID drops may be able to prevent or minimize the deleterious effects of macular swelling after epiretinal membrane surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PPV-MP + Placebo (Saline drops) | Placebo Comparator | PPV-MP= pars plana vitrectomy membrane peel |
|
| PPV-MP + Ketorolac 0.5% | Active Comparator | PPV-MP= pars plana vitrectomy membrane peel |
|
| PhacoVit-MP + Placebo (Saline drops) | Placebo Comparator | PhacoVit-MP= phacovitrectomy membrane peel |
|
| PhacoVit-MP + Ketorolac 0.5%. | Active Comparator | PhacoVit-MP= phacovitrectomy membrane peel |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ketorolac 0.5% | Drug | Four-times a day starting one week before surgery and continued for 4 weeks post surgery. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in macular volume from baseline. | Before surgery, at 1 week, 1 month, and 1 year after surgery. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jeff Gale, MD, FRCSC | Queen's University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Ophthalmology, Hotel Dieu Hospital, Queen's University | Kingston | Ontario | K7L 3N6 | Canada |
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| ID | Term |
|---|---|
| D008269 | Macular Edema |
| D019773 | Epiretinal Membrane |
| ID | Term |
|---|---|
| D008268 | Macular Degeneration |
| D012162 | Retinal Degeneration |
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D020911 | Ketorolac Tromethamine |
| ID | Term |
|---|---|
| D007213 | Indomethacin |
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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|
| Saline drops | Other | Four-times a day starting one week before surgery and continued for 4 weeks post surgery. |
|
| D006571 | Heterocyclic Compounds |