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| ID | Type | Description | Link |
|---|---|---|---|
| ZincTab |
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| Name | Class |
|---|---|
| Université Polytechnique de Bobo-Dioulasso | OTHER |
| Helen Keller International | OTHER |
| Nutriset | INDUSTRY |
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The study aims to compare the effects of two different formulations of zinc supplements on plasma zinc concentrations among young Burkinabe children.
1) To investigate the effects of short-term zinc supplementation, provided either as a dispersible tablet containing zinc sulfate ("ZinCfant," Nutriset Ltd; Malaunay, France) or as a liquid ZnSO4 solution, on changes in serum zinc concentration, compared with a placebo in young Burkinabe children; and 2) to assess the relationship between change in serum zinc concentration and the presence of altered intestinal permeability within each treatment group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Zinc syrup | Experimental | Liquid Zinc Syrup (ZnSO4) solution provided daily |
|
| Zinc tablet | Experimental | Dispersible zinc tablets provided daily |
|
| Placebo | Placebo Comparator | Liquid placebo supplement provided daily |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Liquid zinc syrup | Dietary Supplement | Liquid zinc syrup containing 5 mg zinc as zinc sulfate |
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| Measure | Description | Time Frame |
|---|---|---|
| Plasma zinc concentration | 3 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kenneth H Brown, MD | University of California, Davis | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Toussiana Health District | Touziana | Burkina Faso |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21871635 | Result | Wessells KR, Ouedraogo ZP, Rouamba N, Hess SY, Ouedraogo JB, Brown KH. Short-term zinc supplementation with dispersible tablets or zinc sulfate solution yields similar positive effects on plasma zinc concentration of young children in Burkina Faso: a randomized controlled trial. J Pediatr. 2012 Jan;160(1):129-35.e3. doi: 10.1016/j.jpeds.2011.06.051. Epub 2011 Aug 25. | |
| 30976780 |
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| ID | Term |
|---|---|
| D015032 | Zinc |
| ID | Term |
|---|---|
| D019216 | Metals, Heavy |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D028561 | Transition Elements |
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| Zinc tablet | Dietary Supplement | Dispersible zinc tablet containing 5 mg zinc |
|
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| Liquid placebo supplement | Dietary Supplement | Liquid placebo supplement containing 0 mg zinc |
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| Wessells KR, Peerson JM, Brown KH. Within-individual differences in plasma ferritin, retinol-binding protein, and zinc concentrations in relation to inflammation observed during a short-term longitudinal study are similar to between-individual differences observed cross-sectionally. Am J Clin Nutr. 2019 May 1;109(5):1484-1492. doi: 10.1093/ajcn/nqz014. |
| 25411038 | Derived | Wessells KR, Hess SY, Ouedraogo ZP, Rouamba N, Ouedraogo JB, Brown KH. Asymptomatic malaria infection affects the interpretation of biomarkers of iron and vitamin A status, even after adjusting for systemic inflammation, but does not affect plasma zinc concentrations among young children in Burkina Faso. J Nutr. 2014 Dec;144(12):2050-8. doi: 10.3945/jn.114.200345. Epub 2014 Oct 1. |
| 23689263 | Derived | Wessells KR, Hess SY, Rouamba N, Ouedraogo ZP, Kellogg M, Goto R, Duggan C, Ouedraogo JB, Brown KH. Associations between intestinal mucosal function and changes in plasma zinc concentration following zinc supplementation. J Pediatr Gastroenterol Nutr. 2013 Sep;57(3):348-55. doi: 10.1097/MPG.0b013e31829b4e9e. |
| D008670 |
| Metals |