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| Name | Class |
|---|---|
| Université d'Abomey-Calavi | OTHER |
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The general objective of this study is to determine the effect of the daily consumption of zinc-fortified water provided by the LSF-filter on zinc status and diarrhea rates in school age children from rural areas characterized by a high risk of zinc deficiency and by elevated stunting prevalence.
A double-blind efficacy study will be carried out over 4 months in school age children enrolled in a primary school equipped with a water pump, in the rural area of the commune of Natitingou, Benin. Participating children will be randomly assigned to one of two groups of intervention or control. On a daily basis, all children will consume a defined quantity of pump-water outside of meals. The water offered to children in the first group of intervention will be previously filtered and zinc-fortified by the LSF-filter; the children in the second group will receive water that has been filtered only. A nutrition survey will provide an indication of dietary zinc intake. The effect of enriched water consumption on children's zinc status will be evaluated by analyzing the concentration of zinc in serum at baseline, midpoint and endpoint of the intervention. Diarrhea rates will be monitored by recording episodes of diarrhea.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pump water | No Intervention | Untreated pump water (pump water recognised as improved water source by WHO) | |
| Filtered water | Placebo Comparator | Pump water purified by the LSF-filtering device |
|
| Zinc water | Experimental | Pump water purified and zinc-fortified by the LSF-filtering device |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| LSF-filtering device | Device | LifeStraw Family is a water purification device that by means of hollow fibres removes solid particles (<0.5 NTU turbidity reduction), bacteria (>Log 6 reduction), viruses (>Log 4 reduction) and cysts (>Log 3 reduction). Zinc fortification is provided by a chamber housing a zinc releasing glass-plate that is placed annexed to the hollow fibre column. It is estimated that the LSF can provide about 5 mg of zinc/l of filtered water. By consuming daily a portion of 0.6 litres of enriched water, >100% of the age-specific estimated physiologic requirement would be covered, assuming a fractional absorption of 40%. |
| Measure | Description | Time Frame |
|---|---|---|
| Zinc status | Serum zinc concentration | Baseline, midpont (varying between weeks 5-20), endpoint (week 22) |
| Measure | Description | Time Frame |
|---|---|---|
| Inflammation status | Concentration of CRP in serum | Baseline, midpoint (varying between weeks 5-20), endpoint (week 22) |
| Iron status | Haemoglobin level |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michael B Zimmermann, Prof. Dr.med | ETH Zurich | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kotopounga primary school | Natitingou | Atakora Department | Benin |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26609168 | Derived | Galetti V, Mitchikpe CE, Kujinga P, Tossou F, Hounhouigan DJ, Zimmermann MB, Moretti D. Rural Beninese Children Are at Risk of Zinc Deficiency According to Stunting Prevalence and Plasma Zinc Concentration but Not Dietary Zinc Intakes. J Nutr. 2016 Jan;146(1):114-23. doi: 10.3945/jn.115.216606. Epub 2015 Nov 25. | |
| 26468121 | Derived |
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| Baseline, midpoint (varying between weeks 5-20), endpoint (week 22) |
| Diarrhea incidence | Occurrence of diarrhea episodes monitored over 2 days weekly | Weekly, from baseline through to endpoint |
| Malaria prevalence | Screening of HRP-II antigen | Baseline, midpoint (varying between weeks 5-20), endpoint (week 22) |
| ALRI prevalence | Auscultation and respiratory frequence (no. of chest movements per minute) | At baseline and endpoint |
| Anthropometric indices | Measurement of height, weight and mid-upper arm circumference for the assessment of height-for-age, weight-for-age and BMI-for-age Z-scores. | Baseline, midpoint (varying between weeks 5-20), endpoint (week 22) |
| Galetti V, Kujinga P, Mitchikpe CE, Zeder C, Tay F, Tossou F, Hounhouigan JD, Zimmermann MB, Moretti D. Efficacy of highly bioavailable zinc from fortified water: a randomized controlled trial in rural Beninese children. Am J Clin Nutr. 2015 Nov;102(5):1238-48. doi: 10.3945/ajcn.115.117028. Epub 2015 Oct 14. |