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| ID | Type | Description | Link |
|---|---|---|---|
| 200816610 |
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| Name | Class |
|---|---|
| Helen Keller International | OTHER |
| Cheikh Anta Diop University, Senegal | OTHER |
| Global Alliance for Improved Nutrition | OTHER |
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The purpose of the study is to evaluate the use of plasma zinc concentration for assessing the impact of mass zinc fortification programs.
The objectives of the present study are to determine whether plasma zinc concentration changes in response to additional zinc consumption, as provided by zinc-fortified cereal-based complementary foods fed to adult men (fortified at a level consistent with currently proposed levels). The following specific steps will be completed:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Zinc-fortified bread (10 mg zinc/d) | Experimental | Daily consumption of zinc fortified bread for 1 month |
|
| Zinc fortified bread (20 mg zinc/d) | Experimental | Daily consumption of zinc fortified bread for 1 month. |
|
| Zinc supplemented group | Experimental | Daily consumption of non-fortified bread and daily intake of zinc supplement (10 mg zinc/d) |
|
| Non-fortified group | Placebo Comparator | Daily consumption of non-fortified bread and a placebo supplement for 1 month. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Zinc-fortified bread | Dietary Supplement | Bread made with zinc-fortified wheat flour |
|
| Measure | Description | Time Frame |
|---|---|---|
| Plasma zinc concentration | 1 month |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kenneth H Brown, MD | University of California, Davis | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Helen Keller International | Dakar | Senegal |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21562238 | Derived | Aaron GJ, Ba Lo N, Hess SY, Guiro AT, Wade S, Brown KH. Plasma zinc concentration increases within 2 weeks in healthy Senegalese men given liquid supplemental zinc, but not zinc-fortified wheat bread. J Nutr. 2011 Jul;141(7):1369-74. doi: 10.3945/jn.110.136952. Epub 2011 May 11. |
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| ID | Term |
|---|---|
| D019287 | Zinc Sulfate |
| D014803 | Vitamin B Complex |
| D005492 | Folic Acid |
| ID | Term |
|---|---|
| D013431 | Sulfates |
| D013464 | Sulfuric Acids |
| D013456 | Sulfur Acids |
| D013457 | Sulfur Compounds |
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|
| Zinc supplement | Dietary Supplement | Liquid supplement with zinc |
|
|
| Non-fortified bread | Dietary Supplement | Daily consumption of non-fortified bread |
|
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| Placebo supplement | Dietary Supplement | Daily intake of placebo supplement |
|
|
| D007287 |
| Inorganic Chemicals |
| D017967 | Zinc Compounds |
| D014815 | Vitamins |
| D018977 | Micronutrients |
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D011622 | Pterins |
| D011621 | Pteridines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |