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| Name | Class |
|---|---|
| National Research Agency, France | OTHER |
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Dietary protein differing by their amino acid composition could modulate undesirable metabolic and functional responses to a meal rich in saturated fat and sugars. This study aims at examining the specific effects of dairy protein with different cysteine contents on the postprandial undesirables effects elicited by the ingestion of a high fat meal in overweight subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Casein | Experimental | Protein source in the high fat meal is casein |
|
| Milk soluble protein | Experimental | Protein source in the high fat meal are milk soluble protein |
|
| Alpha lactalbumin | Experimental | Protein source in the high fat meal is alpha-lactalbumin |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Postprandial metabolic and functional measures | Dietary Supplement | After ingestion of a high fat meal containing the different protein sources, the subjects undergo a series of measures of endothelial dysfunction and blood and urine sampling for the assessment of proinflammatory cytokines levels and metabolomics determinations. |
| Measure | Description | Time Frame |
|---|---|---|
| Endothelial dysfunction | 0-2-4-6 hours (after meal ingestion) |
| Measure | Description | Time Frame |
|---|---|---|
| Postprandial inflammation | 0-0.5-1-1.5-2-3-4-6 hours (after meal ingestion) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Robert Benamouzig, MD, Ph. D | Assistance Publique - Hôpitaux de Paris | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre de recherche sur volontaires | Bobigny | 93 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29878266 | Derived | Pujos-Guillot E, Brandolini-Bunlon M, Fouillet H, Joly C, Martin JF, Huneau JF, Dardevet D, Mariotti F. Metabolomics Reveals that the Type of Protein in a High-Fat Meal Modulates Postprandial Mitochondrial Overload and Incomplete Substrate Oxidation in Healthy Overweight Men. J Nutr. 2018 Jun 1;148(6):876-884. doi: 10.1093/jn/nxy049. | |
| 26491119 |
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| ID | Term |
|---|---|
| D050177 | Overweight |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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|
| Mariotti F, Valette M, Lopez C, Fouillet H, Famelart MH, Mathe V, Airinei G, Benamouzig R, Gaudichon C, Tome D, Tsikas D, Huneau JF. Casein Compared with Whey Proteins Affects the Organization of Dietary Fat during Digestion and Attenuates the Postprandial Triglyceride Response to a Mixed High-Fat Meal in Healthy, Overweight Men. J Nutr. 2015 Dec;145(12):2657-64. doi: 10.3945/jn.115.216812. Epub 2015 Oct 21. |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |