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There are many treatments for chronic tinnitus that have been claimed, with varying degrees of statistical reliability. None of those treatments can eradicate the tinnitus completely. Some therapies can reduce the tinnitus symptoms (loudness, annoyance) up to 30%. Thus there is still a need of new treatments that can reduce considerably the tinnitus symptoms and improve the QOL of subjects.
Trial objectives:
These objectives will be assessed:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 : G_1 | Active Comparator | G_1: stimulation for 4 - 6 hours a day, 4 tones per sequence |
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| Group 2 :G_2 | Active Comparator | G_2: stimulation for 4 - 6 hours a day with 12-tone sequences |
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| Group3 : G_3 | Active Comparator | G_3: stimulation for 4 - 6 hours a day, 4 tones per sequence with a signal controlled by EEG measurement |
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| Group 4 : G_4 | Active Comparator | G_4: stimulation for 1 hour a day, 4 tones per sequence |
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| Group5 : G_5 | Placebo Comparator | G_5: stimulation with placebo-tone |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acoustic CR-Stimulator ANM//Technology: Acoustic coordinated reset | Device | The CR-stimulation was originally developed by Prof. Dr. Dr. Peter Tass for deep brain stimulation (DBS). The CR-stimulation through high frequency short pulses causes a neuronal reorganization in the stimulated brain area establishing a normal neuronal activity. Based on intensive modeling studies, experimental proof of concept (POC) animal studies and a clinical POC, we proved that the pathologic activity can be recuperated to a desynchronized/healthy state with the acoustic CR-stimulation. The acoustic CR-stimulation signal will be generated by the ANM CR-Stimulator and transmitted to the ears through a speaker system |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Center Jülich // Institute for Neurosciences and Medicine - Research Center | Jülich | 8185 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22414611 | Result | Tass PA, Adamchic I, Freund HJ, von Stackelberg T, Hauptmann C. Counteracting tinnitus by acoustic coordinated reset neuromodulation. Restor Neurol Neurosci. 2012;30(2):137-59. doi: 10.3233/RNN-2012-110218. | |
| 22846637 | Derived | Adamchic I, Langguth B, Hauptmann C, Tass PA. Psychometric evaluation of visual analog scale for the assessment of chronic tinnitus. Am J Audiol. 2012 Dec;21(2):215-25. doi: 10.1044/1059-0889(2012/12-0010). Epub 2012 Jul 30. |
| Label | URL |
|---|---|
| Counteracting tinnitus by acoustic coordinated reset neuromodulation. Tass PA, Adamchic I, Freund HJ, von Stackelberg T, Hauptmann C. | View source |
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